Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–13 of 13 results
Advanced filters: Author: Jean-Christophe Andrau Clear advanced filters

  • It is not fully understood why genomic loci show asynchronous DNA replication. Here, the authors show that two imprinted gene domains replicate asynchronously between the parental chromosomes due to differential DNA methylation and non-coding RNA, leading to allelic differences.

    • Yui Imaizumi
    • François Charon
    • Robert Feil
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • TAL1 is frequently deregulated in T-cell acute lymphoblastic leukaemias, but the mechanism remains largely unclear. Here the authors show that microinsertions upstream of TAL1 cause its epigenetic reactivation, and that the mode of TAL1activation correlates with prognosis.

    • Jean-Marc Navarro
    • Aurore Touzart
    • Bertrand Nadel
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Chromatin has been implicated in splicing regulation, but whether a causal relationship exists between pre-mRNA splicing and histone modification has been unclear. New genome-wide analyses now show that pre-mRNA splicing influences H3K36 trimethylation, and that splicing inhibition impairs the recruitment of H3K36 methyltransferase HYPB/Setd2, while splicing activation has the opposite effect.

    • Sérgio Fernandes de Almeida
    • Ana Rita Grosso
    • Maria Carmo-Fonseca
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 977-983

  • The ability of HIV to alternate between acute and latent forms is thought to rely on a transcriptional feedback loop where polymerase pausing is released by the viral protein Tat. Here, the authors show that viral genome transcription can occur in a burst-like stochastic manner in the absence of Tat.

    • Katjana Tantale
    • Encar Garcia-Oliver
    • Edouard Bertrand
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-20

  • Using quantitative imaging and monitoring transcription in living embryos, Bellec et al., provide evidence that the pioneer factor GAF acts as a stable mitotic bookmarker during early Drosophila development.

    • Maëlle Bellec
    • Jérémy Dufourt
    • Mounia Lagha
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • The function of nuclear Argonaute proteins in somatic mammalian cells has remained elusive. A new study shows that chromatin-bound Argonaute-1 and Argonaute-2 associate with splicing factors and affect the deposition of histone marks, thereby facilitating spliceosome recruitment and modulating the RNA polymerase II elongation rate. This in turn favors inclusion of variant exons in the mature mRNA.

    • Maya Ameyar-Zazoua
    • Christophe Rachez
    • Annick Harel-Bellan
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 998-1004

  • NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.

    • Stefan Klein-Hessling
    • Ronald Rudolf
    • Amiya Kumar Patra
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Characterizing mammalian gene expression regulation by enhancer elements is complicated by the size and complexity of the genome. Here Vanhille et al.demonstrate CapStarr-Seq, a novel high-throughput method for assessing potential enhancers and deciphering the mechanisms regulating transcription

    • Laurent Vanhille
    • Aurélien Griffon
    • Salvatore Spicuglia
    Research
    Nature Communications
    Volume: 6, P: 1-10

  • Based on genome wide localization of initiating RNA polymerase II, general transcription factors and epigenetic marks in mouse thymocytes, transcription initiation platforms (TIPs) are evidenced, both at promoters and enhancers, as features able to promote tissue-specific expression.

    • Frederic Koch
    • Romain Fenouil
    • Jean-Christophe Andrau
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 956-963

  • Genome-wide binding profiles for eight different chromatin remodellers in mouse embryonic stem (ES) cells are determined at single nucleosome resolution; each remodeller binds at specific nucleosome positions relative to the start of genes, and the same remodeller acts as a positive or negative regulator of transcription depending on the promoter chromatin organization and epigenetic marking of the gene it binds.

    • Maud de Dieuleveult
    • Kuangyu Yen
    • Matthieu Gérard
    Research
    Nature
    Volume: 530, P: 113-116