How heterogeneous nuclear ribonucleoprotein (RNP) F regulates alternative splicing is unclear. Solution structures of three quasi RNA recognition motifs (qRRMs) bound to G-tract RNA now reveal an unusual binding mode, confirmed by mutagenesis and isothermal titration calorimetry analysis. Binding and splicing assays suggest that hnRNP F prevents RNA structure formation.
- Cyril Dominguez
- Jean-François Fisette
- Frédéric H-T Allain
