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Showing 1–2 of 2 results
Advanced filters: Author: Jean-François Lucier Clear advanced filters

  • Although splice isoforms have been observed to change in cancerous cells, the effect of these changes has not always been clear. Using antisense technology, cancer-associated isoforms have now been manipulated in cell lines. The results indicate that shifting splicing patterns of SYK can contribute to cell-cycle changes and anchorage-independent growth and that this change is also triggered by EGF signaling.

    • Panagiotis Prinos
    • Daniel Garneau
    • Sherif Abou Elela
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 673-679

  • A large-scale screen for changes in alternative splice forms in cancer now reveals that almost half of the active alternative splicing events are shifted in breast and ovarian cancer tissues. In addition, many of these changes occur near consensus binding sequences for FOX2 binding sites. This correlates with changes in Fox2 expression or splicing in tissues assessed, and FOX2 depletion results in similar shifts in splice isoforms.

    • Julian P Venables
    • Roscoe Klinck
    • Sherif Abou Elela
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 670-676