Telomere shortening is a hallmark of aging and genetic telomerase deficiency causes premature aging phenotypes and reduces lifespan. Here the authors show that gut-specific telomerase expression is sufficient to rescue aging phenotypes and extend the lifespan of telomerase-deficient zebrafish, as well as ameliorate signs of aging in wild-type animals.
- Mounir El Maï
- Malia Bird
- Miguel Godinho Ferreira
