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Showing 1–6 of 6 results
Advanced filters: Author: Jean-Michel Lacroix Clear advanced filters

  • Current mapping of fork progression in the human genome suffers from drastically low throughput. Here, the authors introduce ForkML, a nanopore sequencing-based method automatically positioning thousands of individual fork velocities by tracking BrdU incorporation into asynchronously growing cells.

    • Victoria Rojat
    • Diletta Ciardo
    • Benoît Le Tallec
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-9

  • Current temporal studies of DNA replication are either complex or low-resolution. Here, the authors introduce Nanotiming, a simple and inexpensive method producing high-resolution, telomere-to-telomere replication timing profiles through BrdU-mediated capture of dTTP pool expansion in S phase.

    • Bertrand Theulot
    • Alan Tourancheau
    • Benoît Le Tallec
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Theulot et al. introduce NanoForkSpeed, a nanopore sequencing-based method to map individual replication fork velocities on entire genomes. NFS shows that fork speed is uniform across yeast chromosomes except for a marked slowdown at pausing sites.

    • Bertrand Theulot
    • Laurent Lacroix
    • Benoît Le Tallec
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Sodium/proton exchangers (NHEs) are critical regulators of pH within the cell and the extracellular microenvironment. Here, the authors show that hypoxia induces mobilization of NHE6 from endosomal compartment to the plasma membrane in a PKC-dependent manner inducing hyper acidification of endosomes and drug resistance.

    • Fabrice Lucien
    • Pierre-Paul Pelletier
    • Claire M. Dubois
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • As discussed in this Review, thyroid cancer tissue alters the metabolism of iodide by affecting gene expression and post-transcriptional processes and can thereby decrease delivery of radioiodide during screening and therapy. This Review details these processes and discusses the clinical implications for different patient groups.

    • Martin Schlumberger
    • Ludovic Lacroix
    • Jean-Michel Bidart
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 3, P: 260-269

  • Thermal transport in semiconductor thin films deviates from conventional Brownian motion, exhibiting superdiffusive behaviour. Here, pump-probe thermoreflectance measurements on InGaAs enable the investigation of heat propagation over an extended bandwidth ranging from a few kHz to 100 GHz.

    • Ahmad Zenji
    • Gilles Pernot
    • Stefan Dilhaire
    ResearchOpen Access
    Communications Materials
    Volume: 5, P: 1-9