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Showing 1–2 of 2 results
Advanced filters: Author: Jeanette E. Villanueva Clear advanced filters

  • A20, encoded by TNFAIP3, is a negative-feedback inhibitor of NF-κB. Grey and colleagues identify natural human variants of TNFAIP3, which lower A20 activity and increase autoinflammatory responses. These alleles were inherited by descendants of Denisovans who crossed the Wallace Line to inhabit Oceania.

    • Nathan W. Zammit
    • Owen M. Siggs
    • Shane T. Grey
    Research
    Nature Immunology
    Volume: 20, P: 1299-1310

  • The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

    • Sunil K. Ahuja
    • Muthu Saravanan Manoharan
    • Weijing He
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-31