Nature Search

Male lions in large coalitions gain reproductive advantages

J. David Bygott
Brian C. R. Bertram
Jeannette P. Hanby
Research20 Dec 1979
Nature

Volume: 282, P: 839-841
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
X-linked recessive inheritance of radial ray deficiencies in a family with four affected males

Robert-Jan H Galjaard
Naci Kostakoglu
Peter Heutink
Research14 Sept 2001
European Journal of Human Genetics

Volume: 9, P: 653-658
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

Immunoglobulin gene rearrangements occur in an organized, temporal way. Skok and colleagues show that immunoglobulin alleles 'pair' to coordinate cleavage and allelic availability.

Susannah L Hewitt
Bu Yin
Jane A Skok
Research17 May 2009
Nature Immunology

Volume: 10, P: 655-664
Epigenomics and transcriptomics profiles of developing zebrafish heart cells

Gulrez Chahal
Michael P. Eichenlaub
Mirana Ramialison
ResearchOpen Access07 Oct 2025
Scientific Data

Volume: 12, P: 1-10
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

David V. Conti
Burcu F. Darst
Christopher A. Haiman
Research04 Jan 2021
Nature Genetics

Volume: 53, P: 65-75
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of blood pressure phenotypes in individuals of European, East Asian and South Asian ancestry. They find trait-associated SNPs at 12 loci, some of which are associated with methylation at nearby CpG sites.

Norihiro Kato
Marie Loh
John C Chambers
Research21 Sept 2015
Nature Genetics

Volume: 47, P: 1282-1293
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

Alexander Teumer
Yong Li
Anna Köttgen
ResearchOpen Access11 Sept 2019
Nature Communications

Volume: 10, P: 1-19
Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries

High levels of extended spectrum beta-lactamase (ESBL) and carbapenemase encoding genes were detected in bacterial isolates causing neonatal sepsis in LMICs. Authors assess the in vitro activity of three antibiotics (fosfomycin, flomoxef and amikacin) in combination against ESBL-producing Klebsiella pneumoniae and Escherichia coli isolates.

Biljana Kakaraskoska Boceska
Tuba Vilken
Herman Goossens
ResearchOpen Access10 May 2024
Nature Communications

Volume: 15, P: 1-12
A catalog of genetic loci associated with kidney function from analyses of a million individuals

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

Matthias Wuttke
Yong Li
Cristian Pattaro
Research31 May 2019
Nature Genetics

Volume: 51, P: 957-972
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
A new algorithm DEtectS critical Congenital Heart Disease at different altitudes: ANDES-CHD study

Katia Bravo-Jaimes
Tania Vasquez-Loarte
Jeannette Lin
Research02 Feb 2024
Journal of Perinatology

Volume: 44, P: 373-378
Bi-directional associations between maternal and infant sleep, and maternal mental health from late pregnancy to 2 years postpartum

Laura Astbury
Meagan E. Crowther
Bei Bei
ResearchOpen Access05 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Anqi Wang
Jiayi Shen
Christopher A. Haiman
Research09 Nov 2023
Nature Genetics

Volume: 55, P: 2065-2074
Bipolar androgen therapy plus olaparib in men with metastatic castration-resistant prostate cancer

Michael T. Schweizer
Roman Gulati
Evan Y. Yu
Research23 Dec 2022
Prostate Cancer and Prostatic Diseases

Volume: 26, P: 194-200
Vascular malperfusion and abruption are prevalent in placentas from pregnancies with congenital heart disease and not associated with cardiovascular risk

Marie Altendahl
Thalia Mok
Yalda Afshar
ResearchOpen Access25 Jan 2023
Scientific Reports

Volume: 13, P: 1-8
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Zhang et al. show that the poly(GA) proteins produced in patients with C9ORF72 repeat expansions cause neurodegeneration and behavioral abnormalities when expressed in mice. The emergence of these phenotypes requires poly(GA) aggregation, and poly(GA) inclusions sequester HR23 proteins involved in proteasomal degradation, as well as proteins involved in nucleocytoplasmic transport.

Yong-Jie Zhang
Tania F Gendron
Leonard Petrucelli
Research21 Mar 2016
Nature Neuroscience

Volume: 19, P: 668-677
Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

David V. Conti
Burcu F. Darst
Christopher A. Haiman
Amendments and Corrections20 Jan 2021
Nature Genetics

Volume: 53, P: 413
Low copy number of the salivary amylase gene predisposes to obesity

Mario Falchi, Philippe Froguel and colleagues report association of a multi-allelic copy number variant encompassing the salivary amylase gene AMY1 with body mass index and risk of obesity.

Mario Falchi
Julia Sarah El-Sayed Moustafa
Philippe Froguel
Research30 Mar 2014
Nature Genetics

Volume: 46, P: 492-497
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Wanqing Wen
Norihiro Kato
Xiao-Ou Shu
ResearchOpen Access20 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
The changing thermal state of permafrost

Permafrost thaw is directly governed by the thermal characteristics of the frozen ground. This Review outlines the status of and mechanisms influencing the thermal state of permafrost, revealing widespread increases in permafrost temperatures and active-layer thicknesses.

Sharon L. Smith
H. Brendan O’Neill
Vladimir E. Romanovsky
Reviews11 Jan 2022
Nature Reviews Earth & Environment

Volume: 3, P: 10-23
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.

Thomas W. Winkler
Humaira Rasheed
Iris M. Heid
ResearchOpen Access13 Jun 2022
Communications Biology

Volume: 5, P: 1-20
Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis

Valery Fuh-Ngwa
Yuan Zhou
Bruce V. Taylor
ResearchOpen Access11 Nov 2022
Scientific Reports

Volume: 12, P: 1-13
Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

Roshan A. Karunamuni
Minh-Phuong Huynh-Le
Tyler M. Seibert
Research14 Jun 2021
Prostate Cancer and Prostatic Diseases

Volume: 25, P: 229-237
Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies

Matthew R. Collinson-Pautz
Wei-Chun Chang
Aaron E. Foster
ResearchOpen Access28 Feb 2019
Leukemia

Volume: 33, P: 2195-2207
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Jari Lahti
Samuli Tuominen
Katri Räikkönen
ResearchOpen Access16 Aug 2022
Molecular Psychiatry

Volume: 27, P: 4419-4431
Cilia distribution and polarity in the epithelial lining of the mouse middle ear cavity

Wenwei Luo
Hong Yi
Ping Chen
ResearchOpen Access30 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Effect of blood pressure on the retinal vasculature in a multi-ethnic Asian population

V Swetha E Jeganathan
Charumathi Sabanayagam
Tien Yin Wong
Research28 Aug 2009
Hypertension Research

Volume: 32, P: 975-982

Search

Male lions in large coalitions gain reproductive advantages

Diminishing benefits of urban living for children and adolescents’ growth and development

X-linked recessive inheritance of radial ray deficiencies in a family with four affected males

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

Epigenomics and transcriptomics profiles of developing zebrafish heart cells

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Repositioning of the global epicentre of non-optimal cholesterol

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

A new algorithm DEtectS critical Congenital Heart Disease at different altitudes: ANDES-CHD study

Bi-directional associations between maternal and infant sleep, and maternal mental health from late pregnancy to 2 years postpartum

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Bipolar androgen therapy plus olaparib in men with metastatic castration-resistant prostate cancer

Vascular malperfusion and abruption are prevalent in placentas from pregnancies with congenital heart disease and not associated with cardiovascular risk

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Low copy number of the salivary amylase gene predisposes to obesity

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

The changing thermal state of permafrost

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Cilia distribution and polarity in the epithelial lining of the mouse middle ear cavity

Effect of blood pressure on the retinal vasculature in a multi-ethnic Asian population

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