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Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties

Coagulation factor IX (FIX) contributes to hemostasis through both plasma activity and binding to extravascular collagen IV. Here, the authors show that collagen binding of albumin-fused hyperactive FIX can be engineered to tailor the pharmacokinetics, distribution, and functional properties in mice for tailored short- or long-term hemophilia B therapy.

Kristin Hovden Aaen
Maria Francesca Testa
Jan Terje Andersen
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-15
An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

Compared with intramuscular vaccine, intranasal vaccination has easier administration and local responses, but efficient antigen delivery presents an obstacle. Here the authors test an intranasal subunit vaccine fused to albumin to facilitate FcRn-mediated trans-mucosal antigen transport and demonstrate protective immunity in mouse models.

Aina Karen Anthi
Anette Kolderup
Jan Terje Andersen
ResearchOpen Access01 May 2025
Nature Communications

Volume: 16, P: 1-16
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules

The development of IgG and albumin-based therapeutics with increased half-lives needs more efficient screening procedures. Here the authors report a human endothelial cell-based recycling assay enabling screening of IgG and albumin variants without chemical labelling and prior to animal testing.

Algirdas Grevys
Jeannette Nilsen
Jan Terje Andersen
ResearchOpen Access12 Feb 2018
Nature Communications

Volume: 9, P: 1-14
Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end

Cleavage of albumin by carboxypeptidase A in vivo reduces its binding to FcRn and plasma half-life. An albumin engineering strategy (QMP) compensates for the poor PK properties resulting from cleavage, as demonstrated for a GLP-1 albumin fusion

Jeannette Nilsen
Kristin Hovden Aaen
Jan Terje Andersen
ResearchOpen Access26 May 2025
Communications Biology

Volume: 8, P: 1-17
Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation

Two orthogonal mass spectrometry techniques reveal that both the Fc and Fab domains of IgGs make direct interactions with FcRn, which could inform the engineering of new improved therapeutic IgGs.

Esben Trabjerg
Jeannette Nilsen
Kasper D. Rand
ResearchOpen Access12 Jun 2025
Communications Biology

Volume: 8, P: 1-13
An intact C-terminal end of albumin is required for its long half-life in humans

Nilsen et al. show that structural alterations in the last C-terminal α-helix of albumin strongly reduce its binding to the neonatal Fc receptor, decreasing the half-life of albumin in humans. This study suggests the structural requirement of the C-terminal of albumin for its long plasma half-life, providing insights into the design of albumin used to carry drugs.

Jeannette Nilsen
Esben Trabjerg
Jan Terje Andersen
ResearchOpen Access20 Apr 2020
Communications Biology

Volume: 3, P: 1-11
Human and mouse albumin bind their respective neonatal Fc receptors differently

Jeannette Nilsen
Malin Bern
Jan Terje Andersen
ResearchOpen Access02 Oct 2018
Scientific Reports

Volume: 8, P: 1-12

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