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FOXL2 posttranslational modifications mediated by GSK3β determine the growth of granulosa cell tumours

The majority of ovarian granulosa tumours harbour the C134W mutation in FOXL2 but the mechanism of tumorigenesis is largely unknown. Here, Kim et al. show that mutant FOXL2 is hyperphosphorylated by GSK3β, which targets the protein for degradation, and find that GSK3β inhibition represses the growth of ovarian granulosa cells.

Jae-Hong Kim
Yong-Hak Kim
Jeehyeon Bae
Research03 Jan 2014
Nature Communications

Volume: 5, P: 1-13
5′-tRNA^Gly(GCC) halves generated by IRE1α are linked to the ER stress response

RNA fragments derived from cleaved transfer RNAs play roles in gene regulation and cell proliferation. Here, the authors report that upon ER stress, an ER ribonuclease produces a specific tRNA fragment that promotes cancer cell proliferation and modulates mRNA alternative splicing.

Hanyong Jin
Ji-Hyun Yeom
Kangseok Lee
ResearchOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Divergent rRNAs as regulators of gene expression at the ribosome level

In Vibrio vulnificus, ribosomes containing variable rRNAs encoded by the rrnI operon (I-ribosomes) preferentially translate a subset of mRNAs involved in bacterial adaptation of environmental changes, establishing divergent rRNAs as regulators of gene expression.

Wooseok Song
Minju Joo
Kangseok Lee
Research04 Feb 2019
Nature Microbiology

Volume: 4, P: 515-526
FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku

The Ku complex, formed by XRCC5/6 heterodimer, binds to double strand break (DSB) ends, initiating non homologous end joining (NHEJ) and preventing homologous recombination (HR). Here, the authors reveal that FOXL2, a forkhead family transcriptional factor, directs DSB repair pathway choice by acetylation-dependent binding to Ku.

Hanyong Jin
Boeun Lee
Jeehyeon Bae
ResearchOpen Access24 Apr 2020
Nature Communications

Volume: 11, P: 1-17
Guanylate-binding proteins induce apoptosis of leukemia cells by regulating MCL-1 and BAK

Yongyang Luo
Hanyong Jin
Jeehyeon Bae
ResearchOpen Access22 Jul 2021
Oncogenesis

Volume: 10, P: 1-12
LRIG2 is a growth suppressor of Hec-1A and Ishikawa endometrial adenocarcinoma cells by regulating PI3K/AKT- and EGFR-mediated apoptosis and cell-cycle

Dae-Shik Suh
Si Eun Park
Jeehyeon Bae
ResearchOpen Access23 Jan 2018
Oncogenesis

Volume: 7, P: 1-11
IER3 is a crucial mediator of TAp73β-induced apoptosis in cervical cancer and confers etoposide sensitivity

Hanyong Jin
Dae-Shik Suh
Jeehyeon Bae
ResearchOpen Access10 Feb 2015
Scientific Reports

Volume: 5, P: 1-11
Antimicrobial peptide-loaded gold nanoparticle-DNA aptamer conjugates as highly effective antibacterial therapeutics against Vibrio vulnificus

Boeun Lee
Jonggwan Park
Jeehyeon Bae
ResearchOpen Access19 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Downregulation of DNA methylation enhances differentiation of THP-1 cells and induces M1 polarization of differentiated macrophages

Junyoung Park
Yongyang Luo
Sang Beom Seo
ResearchOpen Access12 Aug 2023
Scientific Reports

Volume: 13, P: 1-17
Metabolic and lipidomic investigation of the antiproliferative effects of coronatine against human melanoma cells

Hye-Youn Kim
Hanyong Jin
Hyung-Kyoon Choi
ResearchOpen Access28 Feb 2019
Scientific Reports

Volume: 9, P: 1-13
Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling

Hye-Youn Kim
Hwanhui Lee
Hyung-Kyoon Choi
ResearchOpen Access18 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134W)

J-H Kim
S Yoon
J Bae
Research29 Nov 2010
Oncogene

Volume: 30, P: 1653-1663
Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells

H Jin
K Lee
J Bae
ResearchOpen Access14 Mar 2016
Oncogene

Volume: 35, P: 5106-5118

Search

FOXL2 posttranslational modifications mediated by GSK3β determine the growth of granulosa cell tumours

5′-tRNA^Gly(GCC) halves generated by IRE1α are linked to the ER stress response

Divergent rRNAs as regulators of gene expression at the ribosome level

FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku

Guanylate-binding proteins induce apoptosis of leukemia cells by regulating MCL-1 and BAK

LRIG2 is a growth suppressor of Hec-1A and Ishikawa endometrial adenocarcinoma cells by regulating PI3K/AKT- and EGFR-mediated apoptosis and cell-cycle

IER3 is a crucial mediator of TAp73β-induced apoptosis in cervical cancer and confers etoposide sensitivity

Antimicrobial peptide-loaded gold nanoparticle-DNA aptamer conjugates as highly effective antibacterial therapeutics against Vibrio vulnificus

Downregulation of DNA methylation enhances differentiation of THP-1 cells and induces M1 polarization of differentiated macrophages

Metabolic and lipidomic investigation of the antiproliferative effects of coronatine against human melanoma cells

Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling

Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134W)

Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells

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