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Showing 1–6 of 6 results
Advanced filters: Author: Jef K. De Brabander Clear advanced filters

  • The OX2 orexin receptor (OX2R) is a brain GPCR that regulates wakefulness and circadian rhythms in humans, and a potential drug target in insomnia and narcolepsy. Here, the authors use cryo-EM to determine how the first clinically tested OX2R agonist TAK-925 can activate OX2R in a selective manner.

    • Jie Yin
    • Yanyong Kang
    • Daniel M. Rosenbaum
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Gboxin and its chemical derivatives inhibit the growth of primary human and mouse glioblastoma cells, but not of mouse embryonic fibroblasts or neonatal astrocytes, by targeting mitochondrial oxidative phosphorylation complexes.

    • Yufeng Shi
    • S. Kyun Lim
    • Luis F. Parada
    Research
    Nature
    Volume: 567, P: 341-346

  • Niemann-Pick C1 (NPC1) exports low-density-lipoprotein (LDL)-derived cholesterol from lysosomes and comporses a Sterol-Sensing Domain (SSD). Here authors report a cryo-EM structure of human NPC1 bound to itraconazole which reveals how this binding site in the center of NPC1 blocks a putative lumenal tunnel linked to the SSD.

    • Tao Long
    • Xiaofeng Qi
    • Xiaochun Li
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • By seeking to replicate either specific biochemical reactions or the chemical logic employed by cellular machinery, biomimetic synthesis serves to both inform and test proposals for natural product biosynthesis as well as expand and redefine the rules of organic chemistry.

    • Mina Razzak
    • Jef K De Brabander
    Reviews
    Nature Chemical Biology
    Volume: 7, P: 865-875