Ten Dijke and colleagues identify USP4 as a deubiquitylating enzyme (DUB) for the TGF-β receptor I in a screen for ubiquitin-specific proteases affecting TGF-β signalling. USP4, present in a complex with other DUBs, is regulated by AKT-mediated phosphorylation and is required for TGF-β-induced breast cancer cell migration and metastasis.
- Long Zhang
- FangFang Zhou
- Peter ten Dijke