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Functional annotation of chemical libraries across diverse biological processes

Profiling of over 13,000 compounds against yeast gene deletion mutants, defining the differential responses on cells, reveals chemical-genetic interactions that can be used to predict compound function and their target pathways.

Jeff S Piotrowski
Sheena C Li
Charles Boone
Research24 Jul 2017
Nature Chemical Biology

Volume: 13, P: 982-993
Erratum: Functional annotation of chemical libraries across diverse biological processes

Jeff S Piotrowski
Sheena C Li
Charles Boone
Amendments and Corrections21 Nov 2017
Nature Chemical Biology

Volume: 13, P: 1286
Erratum: Functional annotation of chemical libraries across diverse biological processes

Jeff S Piotrowski
Sheena C Li
Charles Boone
Amendments and Corrections21 Nov 2017
Nature Chemical Biology

Volume: 13, P: 1286
Abrupt rise in atmospheric CO₂ overestimates community response in a model plant–soil system

John N. Klironomos
Michael F. Allen
Jeff R. Powell
Research10 Feb 2005
Nature

Volume: 433, P: 621-624
High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds

Shinsuke Ohnuki
Itsuki Ogawa
Yoshikazu Ohya
ResearchOpen Access27 Jan 2022
npj Systems Biology and Applications

Volume: 8, P: 1-16
Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis inE. coli, and that the heme precursor 5-aminolevulinic acid potentiates tellurite toxicity.

Eduardo H. Morales
Camilo A. Pinto
Claudio C. Vásquez
ResearchOpen Access11 May 2017
Nature Communications

Volume: 8, P: 1-12
Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments

Multiplexed sequencing of barcoded mutant collections enables high-throughput, fitness-based condition profiling. BEAN-counter is a computational pipeline for quantifying mutant sensitivity or resistance for a few to thousands of conditions.

Scott W. Simpkins
Raamesh Deshpande
Chad L. Myers
Protocols11 Jan 2019
Nature Protocols

Volume: 14, P: 415-440

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Functional annotation of chemical libraries across diverse biological processes

Erratum: Functional annotation of chemical libraries across diverse biological processes

Erratum: Functional annotation of chemical libraries across diverse biological processes

Abrupt rise in atmospheric CO2 overestimates community response in a model plant–soil system

High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds

Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments

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Abrupt rise in atmospheric CO₂ overestimates community response in a model plant–soil system