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Showing 1–7 of 7 results
Advanced filters: Author: Jeffrey A. M. Coull Clear advanced filters

  • Genome-wide analyses identify variants associated with sinus node dysfunction, distal conduction disease and pacemaker implantation, implicating ion channel function, cardiac developmental programs and sarcomeric structure in bradyarrhythmia susceptibility.

    • Lu-Chen Weng
    • Joel T. Rämö
    • Steven A. Lubitz
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 53-64

  • The wildlife host range of SARS-CoV-2 is currently unknown. Here, the authors report evidence of infection in six common wild animal species (deer mouse, Virginia opossum, raccoon, groundhog, Eastern cottontail, Eastern red bat) out of 23 species tested in Virginia and Washington DC, USA in 2022/2023.

    • Amanda R. Goldberg
    • Kate E. Langwig
    • Joseph R. Hoyt
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Cellular immune responses in rhesus macaques (Macaca mulatta) vaccinated with cytomegalovirus vectors expressing SIV proteins are able to stringently control highly pathogenic SIV infection, regardless of the route of challenge, after systemic spread; immunological and virological analyses of protected macaques followed for up to 3 years suggest that persistent immune surveillance by vaccine-elicited immune responses may have cleared the infection.

    • Scott G. Hansen
    • Michael Piatak Jr
    • Louis J. Picker
    Research
    Nature
    Volume: 502, P: 100-104

  • Dysfunction of the potassium-chloride cotransporter KCC2 has been linked to many neurological diseases, including pain, anxiety and epilepsy. Now, Yves De Koninck and his colleagues report that they have developed a novel small-molecule compound that is orally bioavailable and can activate KCC2 and reduce chronic pain in rats.

    • Martin Gagnon
    • Marc J Bergeron
    • Yves De Koninck
    Research
    Nature Medicine
    Volume: 19, P: 1524-1528