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Showing 1–4 of 4 results
Advanced filters: Author: Jeffrey Bruffaerts Clear advanced filters

  • Functionalizing multiple, distant sites across a molecule is a challenge. Here the authors report a remote functionalization strategy, whereby an initial Heck reaction leads to chain-walking of palladium across a molecule, ring-opening cyclopropanes while retaining the stereochemistry in the product.

    • Sukhdev Singh
    • Jeffrey Bruffaerts
    • Ilan Marek
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • A rapid, modular, stereodivergent and diversity-oriented strategy for constructing acyclic molecular frameworks bearing up to four contiguous and congested stereogenic elements has been developed. This approach can yield the target compounds with remarkably high levels of stereocontrol in only three catalytic steps from commercially available alkynes.

    • Jeffrey Bruffaerts
    • David Pierrot
    • Ilan Marek
    Research
    Nature Chemistry
    Volume: 10, P: 1164-1170

  • A multivariate genome-wide association study highlighting loci that influence both face and brain shape suggesting shared developmental axes during early embryogenesis. These loci did not overlap with those governing behavioral–cognitive traits or neuropsychiatric risk indicating divergence between early brain development and cognitive function.

    • Sahin Naqvi
    • Yoeri Sleyp
    • Peter Claes
    Research
    Nature Genetics
    Volume: 53, P: 830-839

  • In a remote functionalization, reaction occurs at a site distant from the site of initial activation. This Review discusses attempts to achieve this challenging goal with a particular focus on reactions that exploit alkene isomerizations to effect transit of the catalyst from a reactive alkene to a distant sp3 centre.

    • Alexandre Vasseur
    • Jeffrey Bruffaerts
    • Ilan Marek
    Reviews
    Nature Chemistry
    Volume: 8, P: 209-219