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Showing 1–15 of 15 results
Advanced filters: Author: Jeffrey D Orth Clear advanced filters

  • Neuronal recordings show that primate superior colliculus encodes learned abstract visual categories. The authors demonstrate that it plays a causal role in categorization behavior, independent of its role in spatial orienting.

    • Barbara Peysakhovich
    • Ou Zhu
    • David J. Freedman
    Research
    Nature Neuroscience
    Volume: 27, P: 1999-2008

  • Neuropixels recordings from the language-dominant prefrontal cortex reveal a structured organization of planned words, an encoding cascade of phonetic representations by prefrontal neurons in humans and a cellular process that could support the production of speech.

    • Arjun R. Khanna
    • William Muñoz
    • Ziv M. Williams
    ResearchOpen Access
    Nature
    Volume: 626, P: 603-610

  • Comparison of genome-wide association studies of HTT CAG repeat expansion in blood to expansion-driven clinical traits in Huntington’s disease identifies shared and distinct modifiers implicating DNA mismatch repair with tissue and cell-type specificity.

    • Jong-Min Lee
    • Zachariah L. McLean
    • Richard H. Myers
    Research
    Nature Genetics
    Volume: 57, P: 1426-1436

  • Makedonka Mitreva and colleagues report the genome sequence and transcriptome analysis of the hookworm Necator americanus, a prevalent soil-transmitted human parasite and the cause of necatoriasis. They develop a hookworm protein microarray to examine the host parasite interaction and immune response, tested on blood samples from 200 individuals in an endemic region.

    • Yat T Tang
    • Xin Gao
    • Makedonka Mitreva
    ResearchOpen Access
    Nature Genetics
    Volume: 46, P: 261-269

  • Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.

    • Jeffrey D Orth
    • Ines Thiele
    • Bernhard Ø Palsson
    Reviews
    Nature Biotechnology
    Volume: 28, P: 245-248

  • To describe the biochemical composition of an organism multiple data sets must be combined and this information can then be used forin silico analysis. By combining metabolism and transcription data, Lerman et al. discovered new regulons and improved the gene annotation for the simple organism Thermotoga maritima.

    • Joshua A. Lerman
    • Daniel R. Hyduke
    • Bernhard O. Palsson
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-10

  • The lysosomal polyamine transporter ATP13A2 controls the cellular polyamine content, and impaired lysosomal polyamine export represents a lysosome-dependent cell death pathway that may be implicated in ATP13A2-associated neurodegeneration.

    • Sarah van Veen
    • Shaun Martin
    • Peter Vangheluwe
    Research
    Nature
    Volume: 578, P: 419-424

  • Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.

    • Simon Haworth
    • Chin Yang Shapland
    • Beate St Pourcain
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Huntington disease (HD) is considered to be a model neurodegenerative disorder, in that it is caused by a single genetic mutation and is amenable to predictive genetic testing, enabling the entire disease course to be studied. Ross et al. describe the natural history of HD, including the timing of emergence of motor, cognitive and emotional impairments. Building on this information, they review recent progress in the development of biomarkers for HD, and potential future roles of these biomarkers in clinical trials.

    • Christopher A. Ross
    • Elizabeth H. Aylward
    • Sarah J. Tabrizi
    Reviews
    Nature Reviews Neurology
    Volume: 10, P: 204-216