Nature Search

Manipulation of Neural Precursors in situ: Induction of Neurogenesis in the Neocortex of Adult Mice

Sanjay S Magavi
Jeffrey D Macklis
Research01 Dec 2001
Neuropsychopharmacology

Volume: 25, P: 816-835
Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex

Distinct neuron subtypes compartmentalize specific functions by differentially localizing and translating specific RNAs. This work identifies dynamic subtype- and stage-specific growth cone molecular machinery during neocortical circuit development.

Priya Veeraraghavan
Anne K. Engmann
Jeffrey D. Macklis
Research29 Dec 2025
Nature Neuroscience

P: 1-11
Molecular logic of neocortical projection neuron specification, development and diversity

Understanding how each of the many diverse subtypes of neurons that make up the cortex are specified during development presents a continuing challenge for developmental neurobiologists. Macklis and colleagues describe recent advances in our understanding of the specification of cortical projection neuron subtype and area identity.

Luciano Custo Greig
Mollie B. Woodworth
Jeffrey D. Macklis
Reviews09 Oct 2013
Nature Reviews Neuroscience

Volume: 14, P: 755-769
Neuronal subtype specification in the cerebral cortex

An increasing number of genes have been identified that control the specification and development of projection neuron subtypes in the neocortex. Macklis and colleagues review recent progress in understanding their function and discuss the implications for progenitor plasticity.

Bradley J. Molyneaux
Paola Arlotta
Jeffrey D. Macklis
Reviews01 Jun 2007
Nature Reviews Neuroscience

Volume: 8, P: 427-437
IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

P Hande Özdinler
Jeffrey D Macklis
Research22 Oct 2006
Nature Neuroscience

Volume: 9, P: 1371-1381
Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation

This work demonstrates subtype-specific molecular fidelity, laminar positioning, long-distance interhemisheric connectivity and electrophysiologic circuit integration by developmentally primed, microtransplanted neurons in postnatal mouse neocortex.

Thomas V. Wuttke
Foivos Markopoulos
Jeffrey D. Macklis
Research05 Mar 2018
Nature Neuroscience

Volume: 21, P: 517-529
Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice, thus offering a potential therapeutic strategy.

Noriyuki Kishi
Jessica L. MacDonald
Jeffrey D. Macklis
ResearchOpen Access29 Jan 2016
Nature Communications

Volume: 7, P: 1-13
SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development

The closely related Sox5 and Sox6 turn out to perform distinct functions during brain development. Maintenance of the ventricular zone neuroepithelium requires Sox6 in the dorsal and Sox5 in the ventral telencephalon. A portion of the interneurons born in ventral telencephalon then express Sox6, which is necessary for their correct migration and phenotypic differentiation.

Eiman Azim
Denis Jabaudon
Jeffrey D Macklis
Research05 Aug 2009
Nature Neuroscience

Volume: 12, P: 1238-1247
Induction of neurogenesis in the neocortex of adult mice

Sanjay S. Magavi
Blair R. Leavitt
Jeffrey D. Macklis
Research22 Jun 2000
Nature

Volume: 405, P: 951-955
New memories from new neurons

Neurons are born throughout adulthood in specific regions of mammalian brains. It now turns out that — in rats at least — these new neurons are essential for the formation of one type of memory.

Jeffrey D. Macklis
News & Views15 Mar 2001
Nature

Volume: 410, P: 314-317
Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex

A subcellular sorting approach enables quantitative analysis of subtypes of growth cones in the brain, and reveals subcellular relationships between local mRNA and local proteomes in developing projection neurons.

Alexandros Poulopoulos
Alexander J. Murphy
Jeffrey D. Macklis
Research09 Jan 2019
Nature

Volume: 565, P: 356-360
Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Sensory input and neuronal activity are crucial for proper morphological development of neurons. Here, Frangeul and colleagues show that membrane excitability is a critical component of dendritic development in mouse somatosensory thalamocortical neurons.

Laura Frangeul
Vassilis Kehayas
Denis Jabaudon
ResearchOpen Access08 Dec 2017
Nature Communications

Volume: 8, P: 1-10
Modeling ALS with motor neurons derived from human induced pluripotent stem cells

In this Review, a collaboration of leading experts in amyotrophic lateral sclerosis (ALS) research present the state of the field regarding the use patient-derived induced pluripotent stem cells to generate motor neurons in vitro. Motor neuron characterization, including transcriptomics, molecular markers, neuron function and electrophysiology, are discussed in the context of maturation and disease.

Samuel Sances
Lucie I Bruijn
Clive N Svendsen
Reviews29 Mar 2016
Nature Neuroscience

Volume: 19, P: 542-553
CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria

The authors encode pixel values of a short motion picture into the DNA of a population of Escherichia coli.

Seth L. Shipman
Jeff Nivala
George M. Church
Research12 Jul 2017
Nature

Volume: 547, P: 345-349
Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes

The authors present a protocol that enables isolation of growth cones and paired somata from any neuronal subtype of the CNS that can be fluorescently labeled by fluid shear forces, ultracentrifugation, fluorescent small particle sorting and FACS.

Anne K. Engmann
John J. Hatch
Jeffrey D. Macklis
Protocols12 Jan 2022
Nature Protocols

Volume: 17, P: 222-251
Stem cell therapies for spinal cord injury

Stem cell therapy has the potential to provide a valuable treatment approach for spinal cord injury, but no consensus yet exists regarding which type of stem cell is likely to be most effective in the clinical setting. In this article, Sahni and Kessler review the various stem cell strategies that have been tested in animal models for the treatment of spinal cord injury, and discuss ongoing clinical trials and future prospects for stem cell therapy in humans.

Vibhu Sahni
John A. Kessler
Reviews15 Jun 2010
Nature Reviews Neurology

Volume: 6, P: 363-372

Search

Manipulation of Neural Precursors in situ: Induction of Neurogenesis in the Neocortex of Adult Mice

Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex

Molecular logic of neocortical projection neuron specification, development and diversity

Neuronal subtype specification in the cerebral cortex

IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation

Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development

Induction of neurogenesis in the neocortex of adult mice

New memories from new neurons

Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Modeling ALS with motor neurons derived from human induced pluripotent stem cells

CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria

Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes

Stem cell therapies for spinal cord injury

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