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Showing 1–8 of 8 results
Advanced filters: Author: Jelle van den Ameele Clear advanced filters

  • Notch signalling plays a key role in cell fate transitions, but how Notch activates distinct regulatory networks in closely related cell types is not well understood. Here the authors profile Notch and RBPJ targets in the developing mouse cortex and reveal how transcription factor occupancy and chromatin remodelling interact to direct differential gene expression during differentiation.

    • Jelle van den Ameele
    • Robert Krautz
    • Andrea H. Brand
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The authors show that the oncogene Bcl6 is necessary for proper cortical neurogenesis in vivo and from embryonic stem cells. BCL6 alters the composition of Notch-dependent transcriptional complexes at the Hes5 promoter, including the recruitment of Sirt1, to promote transition to a neurogenic fate despite active Notch signaling.

    • Luca Tiberi
    • Jelle van den Ameele
    • Pierre Vanderhaeghen
    Research
    Nature Neuroscience
    Volume: 15, P: 1627-1635

  • The last decade has seen major progress in the molecular diagnosis of rare inherited diseases, underpinning gene-targeted therapies that are now in the clinic. However, new treatment development is slow and very expensive. Here, we highlight the opportunities for mitochondrial disorders, the challenges and some of the potential solutions.

    • Carlo Viscomi
    • Jelle van den Ameele
    • Patrick F. Chinnery
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 22, P: 429-430

  • Similar to cancers, somatic mutations might lead to neurodegenerative diseases. Here, the authors perform ultra-deep sequencing of 102 genes in 173 adult human brains, detect somatic mutations in 54 brains, and develop a mathematical model to estimate the frequency of mutated foci in human brains.

    • Michael J. Keogh
    • Wei Wei
    • Patrick F. Chinnery
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12