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Showing 1–9 of 9 results
Advanced filters: Author: Jellert T. Gaublomme Clear advanced filters

  • Single-nucleus RNA-seq enables interrogation of complex tissues but is limited due to batch effects and processing costs. Here the authors use barcoded antibodies against the nuclear pore complex to label nuclei from distinct samples, and develop a computational tool to assign the sample of origin.

    • Jellert T. Gaublomme
    • Bo Li
    • Aviv Regev
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • A global view of the genetic networks regulating the differentiation of TH17 cells is presented, based on temporal expression profiling, computational network reconstruction and validation of predicted interactions by nanowire-mediated siRNA perturbation.

    • Nir Yosef
    • Alex K. Shalek
    • Aviv Regev
    Research
    Nature
    Volume: 496, P: 461-468

  • Latency-associated peptide (LAP) is a membrane-bound form of TGF-β1. Here the authors show that LAP marks a subset of regulatory γδ T cells with innate gut-homing properties, which present antigen and induce CD4+ Foxp3+ in Peyer's patches and lamina propria.

    • Rafael M. Rezende
    • Andre P. da Cunha
    • Howard L. Weiner
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Single-cell profiling studies of the human gastrointestinal tract are increasing, offering an excellent opportunity to generate the first Human Gut Cell Atlas. This Roadmap presents a structured direction towards this goal and provides a detailed overview of the major challenges.

    • Matthias Zilbauer
    • Kylie R. James
    • Keith T. Wilson
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 20, P: 597-614

  • Single-cell RNA sequencing is used to investigate the transcriptional response of 18 mouse bone-marrow-derived dendritic cells after lipopolysaccharide stimulation; many highly expressed genes, such as key immune genes and cytokines, show bimodal variation in both transcript abundance and splicing patterns. This variation reflects differences in both cell state and usage of an interferon-driven pathway involving Stat2 and Irf7.

    • Alex K. Shalek
    • Rahul Satija
    • Aviv Regev
    Research
    Nature
    Volume: 498, P: 236-240