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Showing 1–2 of 2 results
Advanced filters: Author: Jenna Giubilaro Clear advanced filters

  • While Ras is a promising target for cancer therapy, development of inhibitors targeting Ras signaling has proven challenging. Here, the authors report the discovery of Rasarfin, a small molecule from a phenotypic screen on G protein-coupled receptor (GPCR) endocytosis that acts as a dual Ras and ARF6 inhibitor.

    • Jenna Giubilaro
    • Doris A. Schuetz
    • Stéphane A. Laporte
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, which they use to dissect the role of the β-arrestin/β2-adaptin interaction in GPCR signalling.

    • Alexandre Beautrait
    • Justine S. Paradis
    • Michel Bouvier
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16