RCAN1, the regulator of calcineurin phosphatase, interacts with TAK1 kinase binding protein 2 (TAB2). This leads to formation of the signalling complex TAK1-TAB1-TAB2, which phosphorylates RCAN1 and converts it to an activator of the calcineurin-NFAT pathway. Activated calcineurin then switches the signal off by dephopshorylating TAK1 and TAB1.
- Qinghang Liu
- Jennifer Caldwell Busby
- Jeffery D. Molkentin
