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Showing 1–4 of 4 results
Advanced filters: Author: Jennifer H. Kenty Clear advanced filters

  • Hypoxia impairs the efficacy of stem cell-derived islet cell therapy, making it a potential barrier for treatment of type 1 diabetes. Wang et al. identify EDN3 as a key factor that preserves β cell identity and function in hypoxia, offering possible strategies to improve therapeutic outcomes.

    • Xi Wang
    • Shlomi Brielle
    • Douglas A. Melton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression pattern similar to human islet alpha cells and behave as such when transplanted into mice.

    • Quinn P. Peterson
    • Adrian Veres
    • Douglas A. Melton
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with improved insulin secretion.

    • Edwin A. Rosado-Olivieri
    • Kendall Anderson
    • Douglas A. Melton
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Single-cell transcriptional profiling of in vitro human pancreatic β-cell differentiation reveals progenitor and terminal fates, produces a detailed time course of endocrine induction and underpins a lineage model.

    • Adrian Veres
    • Aubrey L. Faust
    • Douglas A. Melton
    Research
    Nature
    Volume: 569, P: 368-373