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Intestinal protection without T cell help

Jennifer Gommerman discusses a 2008 paper by Sidonia Fagarasan and colleagues showing that isolated lymphoid follicles (ILFs) in the gut can function as inductive sites for the generation of IgA-producing plasma cells in the absence of T cell help.

Jennifer L. Gommerman
Research Highlights29 Jan 2020
Nature Reviews Immunology

Volume: 20, P: 275
Author Correction: B cell depletion therapies in autoimmune disease: advances and mechanistic insights

Dennis S. W. Lee
Olga L. Rojas
Jennifer L. Gommerman
Amendments and Corrections26 Nov 2024
Nature Reviews Drug Discovery

Volume: 24, P: 72
Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control

Khader and colleagues show Mycobacterium tuberculosis (Mtb)-specific B cells are needed to recruit T_FH cells into follicular-like structures within lung granulomas to control the Mtb bacilli; however, specific antibodies and many conventional properties of B cells are dispensable.

Rosemary V. Swanson
Ananya Gupta
Shabaana A. Khader
Research03 Apr 2023
Nature Immunology

Volume: 24, P: 855-868
Type 1 immune response reduces seizure risk after traumatic brain injury

A preprint by Mroz et al. reports a role for IFNgamma in protecting against seizures after traumatic brain injury.

Jennifer S. Y. Ahn
Jennifer L. Gommerman
Research Highlights03 Mar 2025
Nature Reviews Immunology

Volume: 25, P: 234
Fine-tuning of dendritic cell biology by the TNF superfamily

Dendritic cells (DCs) are the master regulators of T cell responses to foreign antigens. This Review discusses how the tumour necrosis factor (TNF) superfamily of molecules influences DC biology and the outcome for T cell immune responses.

Leslie Summers deLuca
Jennifer L. Gommerman
Reviews10 Apr 2012
Nature Reviews Immunology

Volume: 12, P: 339-351
What Jane Jacobs has taught me about neuroimmunology

In acknowledgment of Women’s History Month, I have drawn upon timeless concepts from Jane Jacobs’ seminal 1961 book The Death and Life of Great American Cities¹ to describe emerging ideas in neuroimmunology and how we may collectively move the field forward.

Jennifer L. Gommerman
Comments & Opinion01 Mar 2024
Nature Immunology

Volume: 25, P: 381
Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells

Although maturation of dendritic cells can drive autoimmune responses in mice, it remains unclear whether intrinsic factors hold dendritic cells in a resting state. Pamela Ohashi and her colleagues identify a repressive mechanism requiring expression of nuclear factor-κB1 in dendritic cells. Loss of nuclear factor-κB1 results in CD8⁺ T cell activation, TNF-α production and autoimmune diabetes in mice.

Dilan Dissanayake
Håkan Hall
Pamela S Ohashi
Research13 Nov 2011
Nature Medicine

Volume: 17, P: 1663-1667
B cell depletion therapies in autoimmune disease: advances and mechanistic insights

Examining B cell depletion therapy (BCDT), an approved treatment for B cell malignancies, in autoimmune conditions has provided key insights into basic B cell biology. In this Review, Gommerman and colleagues discuss BCDT in autoimmune conditions, highlighting diseases in which BCDT has been clinically effective and the potential and pitfalls for BCDT in autoimmune conditions in which it has not yet been efficacious.

Dennis S. W. Lee
Olga L. Rojas
Jennifer L. Gommerman
Reviews15 Dec 2020
Nature Reviews Drug Discovery

Volume: 20, P: 179-199
Lymphotoxin/LIGHT, lymphoid microenvironments and autoimmune disease

Jennifer L. Gommerman
Jeffrey L. Browning
Reviews01 Aug 2003
Nature Reviews Immunology

Volume: 3, P: 642-655
The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

Class switch recombination (CSR) requires break and repair of immunoglobulin DNA. Here the authors show that the histone deubiquitinase Usp22 is involved in V(D)J recombination and CSR of IgG and IgE, but not IgA, and that IgG CSR is dependent on the canonical c-NHEJ pathway, whereas IgA CSR is more dependent on the alternative A-EJ pathway.

Conglei Li
Thergiory Irrazabal
Alberto Martin
ResearchOpen Access08 Mar 2018
Nature Communications

Volume: 9, P: 1-12
Acquisition of a multifunctional IgA⁺ plasma cell phenotype in the gut

IgA secreting plasma cells in the lamina propria are shown to be an important source of iNOS and TNF required to maintain the homeostatic balance between intestinal microbes and the immune system.

Jörg H. Fritz
Olga Lucia Rojas
Jennifer L. Gommerman
Research11 Dec 2011
Nature

Volume: 481, P: 199-203
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

IL-23 is needed to protect mucosal surfaces from bacterial pathogens. Murphy and colleagues identify a Notch-2-dependent CD11b⁺ dendritic cell population that produces IL-23 and is required for survival after infection with Citrobacter.

Ansuman T Satpathy
Carlos G Briseño
Kenneth M Murphy
Research04 Aug 2013
Nature Immunology

Volume: 14, P: 937-948
Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis

Major advances have been made in disease-modifying therapies for multiple sclerosis, but people with Parkinson disease still lack such treatment options. Drawing on discussions from a symposium held in November 2022, this Roadmap proposes areas for exploration in Parkinson disease using lessons learned from therapeutic development in multiple sclerosis.

Lorraine V. Kalia
Angelica Asis
Jiwon Oh
Reviews07 Oct 2024
Nature Reviews Neurology

Volume: 20, P: 724-737
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node

Conglei Li
Lesley A. Ward
Jennifer L. Gommerman
Research18 Feb 2022
Mucosal Immunology

Volume: 15, P: 418-427
Comparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study

Lawrence Reiter
Johann Greffrath
Aleksandra Pastrak
ResearchOpen Access04 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection

Salma Sheikh-Mohamed
Baweleta Isho
Jennifer L. Gommerman
Research25 Apr 2022
Mucosal Immunology

Volume: 15, P: 799-808

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Intestinal protection without T cell help

Author Correction: B cell depletion therapies in autoimmune disease: advances and mechanistic insights

Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control

Type 1 immune response reduces seizure risk after traumatic brain injury

Fine-tuning of dendritic cell biology by the TNF superfamily

What Jane Jacobs has taught me about neuroimmunology

Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells

B cell depletion therapies in autoimmune disease: advances and mechanistic insights

Lymphotoxin/LIGHT, lymphoid microenvironments and autoimmune disease

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

Acquisition of a multifunctional IgA⁺ plasma cell phenotype in the gut

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis

Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node

Comparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study

Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection

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