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Showing 1–5 of 5 results
Advanced filters: Author: Jennifer M Shipman Clear advanced filters
  • Here, Xiao et al. isolate a large panel of antibodies against human metapneumovirus fusion protein from human B cells, and characterize their epitopes, neutralization activities, and antigen binding specificity, providing a useful framework for understanding the immune response against hMPV.

    • Xiao Xiao
    • Arthur Fridman
    • Lan Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13
  • Crystallographic analysis of human O-GlcNAc hydrolase (hOGA) fragments containing the catalytic domain, including structures in complex with known inhibitors, suggests that OGA is functional as a dimer and defines opportunities for structure-based drug design.

    • Nathaniel L Elsen
    • Sangita B Patel
    • Daniel J Klein
    Research
    Nature Chemical Biology
    Volume: 13, P: 613-615
  • Agonists of the orexin receptor 2 (OX2R) show promise in the treatment of narcolepsy. Cryo-EM structures of active-state OX2R bound to an endogenous peptide agonist and a small-molecule agonist suggest a molecular mechanism that rationalizes both receptor activation and inhibition.

    • Chuan Hong
    • Noel J. Byrne
    • Kaspar Hollenstein
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11
  • Crystal structures of two complexes of the angiotensin II receptor AT2R with distinct tightly bound ligands reveal an active-like state of the receptor, in which helix VIII adopts a non-canonical position that blocks binding of G proteins and β-arrestins.

    • Haitao Zhang
    • Gye Won Han
    • Vadim Cherezov
    Research
    Nature
    Volume: 544, P: 327-332
  • Recent reviewers suggest good books to refresh your mind this summer — from a cultural history of piracy to a scientific tour of the boulevards of Paris.

    • Steven Shapin
    • W. F. Bynum
    • Vaclav Smil
    Books & Arts
    Nature
    Volume: 466, P: 563-566