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Advanced filters: Author: Jennifer R. Ayers-Ringler Clear advanced filters

Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors

Combining proteolysis targeting chimeras that target the same oncogenic cell surface proteins (EGFR, HER2 and MET) as respective antibodies, improved antibody internalization and enhanced the cytotoxicity of a HER2-targeting antibody drug conjugate.

Ezequiel J. Tolosa
Lin Yang
Aaron S. Mansfield
ResearchOpen Access31 Dec 2024
Communications Biology

Volume: 7, P: 1-10
Evaluating therapeutic plasma exchange and protease inhibitors as mechanisms to reduce soluble mesothelin

Katherine E. R. Smith
Jennifer R. Ayers-Ringler
Aaron S. Mansfield
ResearchOpen Access16 Apr 2025
Scientific Reports

Volume: 15, P: 1-9

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Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors

Evaluating therapeutic plasma exchange and protease inhibitors as mechanisms to reduce soluble mesothelin

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