Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Jenny Wegert Clear advanced filters

  • Soft tissue tumors in infants encompass an overlapping spectrum of diseases posing unique diagnostic and clinical challenges. Here, the authors investigate the genetic basis of cryptogenic congenital mesoblastic nephroma and infantile fibrosarcoma lacking the canonical NTRK3-ETV6 fusion gene, and identify therapeutically tractable intragenic rearrangements in EGFR and BRAF.

    • Jenny Wegert
    • Christian Vokuhl
    • Sam Behjati
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-6

  • It remains unclear why some paediatric tumours appear to have such a low mutation burden. Here, the authors shed light on this paradox by analysing Wilms tumours using high resolution and high depth sequencing approaches, finding that - due to an unusual clonal architecture - standard methods significantly underestimate the mutation burden at the cellular level.

    • Henry Lee-Six
    • Taryn D. Treger
    • Sam Behjati
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

    • Susanne N. Gröbner
    • Barbara C. Worst
    • Stefan M. Pfister
    ResearchOpen Access
    Nature
    Volume: 555, P: 321-327

  • Here, the authors describe the history of the efforts to expand knowledge of Wilms tumour biology, genetics, embryonal origin and associated syndromic and familial conditions, and to clinically apply prognostic biomarkers and development of preclinical models.

    • Daniela Perotti
    • Richard D. Williams
    • Kathy Pritchard-Jones
    Reviews
    Nature Reviews Urology
    Volume: 21, P: 158-180

  • In this Review, the authors provide a comprehensive historical overview of the advancements in the understanding of biology and genetics of paediatric renal non-Wilms tumours, and discuss how this information can be used to develop new targeted therapies for these rare cancers.

    • Daniela Perotti
    • Maureen J. O’Sullivan
    • Andrew L. Hong
    Reviews
    Nature Reviews Urology
    Volume: 22, P: 526-543