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Showing 1–5 of 5 results
Advanced filters: Author: Jeong-Mi Lee Clear advanced filters
  • How immune responses arise against microorganisms living on the skin is not fully understood. The discovery that skin maintains its own system to form antibody responses reveals an unexpected vaccination route.

    • Jeong-Mi Lee
    • Peter T. Sage
    News & Views
    Nature
    Volume: 638, P: 894-896
  • TFH cells that express IL-13 are associated with high-affinity IgE responses, but factors controlling their development, transcriptional programming and exact function have remained unclear. Here, Chandrakar et al. find that the transcription factor JunB is required for TFH13 cell maintenance and that TFH13 cells producing IL-21 drive broad germinal center responses to allergen-specific IgG and IgE.

    • Pragya Chandrakar
    • Cody S. Nelson
    • Peter T. Sage
    Research
    Nature Immunology
    Volume: 26, P: 473-483
  • Follicular regulatory T (Tfr) cells modulate germinal center T and B cell responses, but how Tfr may control allograft rejection is still unclear. Here the authors show, using mouse kidney allograft rejection models, that Tfr suppresses the production of pro-inflammatory cytokines and alloreactive antibodies from alloreactive B cells to dampen graft rejection

    • Hengcheng Zhang
    • Manuel A. Podestà
    • Peter T. Sage
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Follicular helper T cells play critical roles in the formation of high affinity antibody responses, but the signals involved in the development of these cells after initial differentiation are poorly understood. Here Podestà, Cavazzoni and colleagues characterise transitionary phases of follicular helper T cell development and how progression through these stages is linked to humoral immunity.

    • Manuel A. Podestà
    • Cecilia B. Cavazzoni
    • Peter T. Sage
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • Expression of the inhibitory receptor PD-1 on regulatory T cells in the tumor microenvironment provides intrinsic stabilization, proliferation and metabolic rewiring signals to restrain tumor immunity.

    • Jeong-Mi Lee
    • Peter T. Sage
    News & Views
    Nature Immunology
    Volume: 24, P: 10-11