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Showing 1–4 of 4 results
Advanced filters: Author: Jeremie Kalfon Clear advanced filters

  • The role of ancestry in target discovery remains to be systematically explored. Here, the authors analyse data from 611 genome scale CRISPR/Cas9 viability experiments in human cell line models as part of The Cancer Dependency Map and identify ancestry-associated genetic dependencies.

    • Sean A. Misek
    • Aaron Fultineer
    • Jesse S. Boehm
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • In cells with microsatellite instability, expanded TA-dinucleotide repeats form cruciform structures that stall replication forks and cause chromosome shattering in the absence of the WRN helicase.

    • Niek van Wietmarschen
    • Sriram Sridharan
    • André Nussenzweig
    Research
    Nature
    Volume: 586, P: 292-298

  • Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.

    • Tanaz Sharifnia
    • Mathias J. Wawer
    • Stuart L. Schreiber
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17