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Showing 1–14 of 14 results
Advanced filters: Author: Jeremy Hoog Clear advanced filters

  • Neil Hunter and colleagues show that the HEI10 ubiquitin ligase regulates meiotic recombination by limiting the colocalization of RNF212 and MSH4-MSH5 to future crossover sites. At later stages, they find that HEI10 accumulates stably at designated crossover sites and facilitates clearance of RNF212 and MSH4-MSH5 complexes to promote the final steps of meiotic recombination.

    • Huanyu Qiao
    • H B D Prasada Rao
    • Neil Hunter
    Research
    Nature Genetics
    Volume: 46, P: 194-199

  • Connecting genomics and proteomics allows the development of more efficient and specific treatments for cancer. Here, the authors develop proteogenomic methods to defining cancer signaling in-vivo starting from core needle biopsies and with application to a HER2 breast cancer focused clinical trial.

    • Shankha Satpathy
    • Eric J. Jaehnig
    • Matthew J. Ellis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Whole-genome analysis of oestrogen-receptor-positive tumours in patients treated with aromatase inhibitors show that distinct phenotypes are associated with specific patterns of somatic mutations; however, most recurrent mutations are relatively infrequent so prospective clinical trials will require comprehensive sequencing and large study populations.

    • Matthew J. Ellis
    • Li Ding
    • Elaine R. Mardis
    ResearchOpen Access
    Nature
    Volume: 486, P: 353-360

  • Massively parallel DNA sequencing allows entire genomes to be screened for genetic changes associated with tumour progression. Here, the genomes of four DNA samples from a 44-year-old African-American patient with basal-like breast cancer were analysed. The samples came from peripheral blood, the primary tumour, a brain metastasis and a xenograft derived from the primary tumour. The findings indicate that cells with a distinct subset of the primary tumour mutation might be selected during metastasis and xenografting.

    • Li Ding
    • Matthew J. Ellis
    • Elaine R. Mardis
    Research
    Nature
    Volume: 464, P: 999-1005

  • Patient-derived xenografts recapitulate major genomic signatures and transcriptome profiles of their original tumours. Here, the authors, performing proteomic and phosphoproteomic analyses of 24 breast cancer PDX models, demonstrate that druggable candidates can be identified based on a comprehensive proteogenomic profiling.

    • Kuan-lin Huang
    • Shunqiang Li
    • Li Ding
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • Neil Hunter and colleagues show that RNF212 is essential for crossing-over during mammalian meiosis and functions to couple chromosome synapsis to the formation of crossover-specific recombination complexes. They further show that selective localization of RNF212 to a subset of recombination sites is a key step in the crossover designation process that serves to stabilize meiosis-specific recombination factors at these sites.

    • April Reynolds
    • Huanyu Qiao
    • Neil Hunter
    Research
    Nature Genetics
    Volume: 45, P: 269-278

  • Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.

    • Shom Goel
    • Molly J. DeCristo
    • Jean J. Zhao
    Research
    Nature
    Volume: 548, P: 471-475

  • The authors applied a correlation-based metric, ‘differential stability’ (DS), to assess reproducibility of gene expression patterning across individual brains, revealing mesoscale genetic organization. The highest DS genes were enriched for brain-related biological annotations, disease associations and drug targets, and their anatomical expression pattern correlated with resting state functional connectivity.

    • Michael Hawrylycz
    • Jeremy A Miller
    • Ed Lein
    Research
    Nature Neuroscience
    Volume: 18, P: 1832-1844