This work describes the identification and characterization of novel small molecule activators of SIRT1, an NAD+-dependent deacetylase that mediates the beneficial effects of caloric restriction. These small molecules are structurally unrelated to, and much more potent than, resveratrol, and improve metabolic function in animal models of diabetes and obesity.
- Jill C. Milne
- Philip D. Lambert
- Christoph H. Westphal
