Disinhibition of neural activity in the spinal cord is implicated in neuropathic pain. Chen et al.show that disinhibition of neural activity arises from a shift in reversal potential of GABA and a decrease in the conductance of presynaptic GABA, which are both regulated by brain-derived neurotrophic factor.
- Jeremy Tsung-chieh Chen
- Da Guo
- Jing Hu