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Showing 1–9 of 9 results
Advanced filters: Author: Jerome M. Karp Clear advanced filters

  • Polyaromatic hydrocarbons, derived from combusted biomass, are influenced by regional wildfire regimes during the Early Triassic, which are coupled with less intense hydrological cycles, altered vegetation succession, and potentially impacted long-term carbon sequestration, according to analyses of hydrocarbon abundances in shales.

    • Franziska R. Blattmann
    • Charline Ragon
    • Clayton R. Magill
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 6, P: 1-8

  • No clinical assay currently exists to classify glioma tumours based on gene expression. Here, the authors develop a DNA methylation-based classifier, Unified Diagnostic Pipeline (UniD) that identifies genomic alterations and gene expression subtypes of gliomas.

    • Jie Yang
    • Qianghu Wang
    • Erik P. Sulman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

    • Jérôme Buard
    • Alec J. Jeffreys
    News & Views
    Nature Genetics
    Volume: 15, P: 327-328

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • The histone chaperone nucleoplasmin (Npm) stores histones H2A/H2B in the egg and embryo. Here, the authors use NMR to show that Npm’s intrinsically disordered tail domain controls histone binding at an acidic stretch, which is autoregulated through direct competition with its basic C-terminus.

    • Christopher Warren
    • Tsutomu Matsui
    • David Shechter
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Allogeneic hematopoietic cell transplantation (allo-HCT) has led to the cure of HIV in one individual, but the underlying mechanisms are unclear. Here, the authors present a model of allo-HCT in SHIV-infected nonhuman primates and show that the SHIV reservoir persists in multiple tissues early after transplantation.

    • Lucrezia Colonna
    • Christopher W. Peterson
    • Leslie S. Kean
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15