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Primate evolution of the recombination regulator PRDM9

PRDM9 is a hybrid sterility gene in mammals; yet its role in primate evolution is unclear. Here, Schwartz et al. identify new PRDM9alleles in 64 primates and show rapid evolution throughout the primate lineage, which suggests that PRDM9 plays a major role in speciation.

Jerrod J. Schwartz
David J. Roach
Jay Shendure
Research08 Jul 2014
Nature Communications

Volume: 5, P: 1-7
Erratum: Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

Brian J O'Roak
Pelagia Deriziotis
Evan E Eichler
Amendments and Corrections28 Mar 2012
Nature Genetics

Volume: 44, P: 471
Colloidal lenses allow high-temperature single-molecule imaging and improve fluorophore photostability

The use of colloidal titanium dioxide particles as lenses enables single-molecule imaging to be performed at temperatures as high as 70 °C.

Jerrod J. Schwartz
Stavros Stavrakis
Stephen R. Quake
Research20 Dec 2009
Nature Nanotechnology

Volume: 5, P: 127-132
Accurate gene synthesis with tag-directed retrieval of sequence-verified DNA molecules

Gene synthesis is currently limited by the need to use error-prone oligonucleotide building blocks. Dial-out PCR overcomes the sequence verification bottleneck by using unique sequence tags and massively parallel sequencing to identify and selectively retrieve error-free DNA molecules of interest from complex mixtures.

Jerrod J Schwartz
Choli Lee
Jay Shendure
Research12 Aug 2012
Nature Methods

Volume: 9, P: 913-915
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

Evan Eichler, Jay Shendure and colleagues sequenced the exomes of 20 sporadic cases of autism spectrum disorder and their unaffected parents. They identified potentially causative de novo mutations in four cases, including a frameshift in FOXP1, a splice-site mutation in GRIN2B and missense variants in SCN1A and LAMC3.

Brian J O'Roak
Pelagia Deriziotis
Evan E Eichler
Research15 May 2011
Nature Genetics

Volume: 43, P: 585-589
Multiplexed, universal probe-based rare variant detection with USE-PCR

John Alvarado
Lucien Jacky
Jerrod J. Schwartz
ResearchOpen Access04 Jul 2025
Scientific Reports

Volume: 15, P: 1-15

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Primate evolution of the recombination regulator PRDM9

Erratum: Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

Colloidal lenses allow high-temperature single-molecule imaging and improve fluorophore photostability

Accurate gene synthesis with tag-directed retrieval of sequence-verified DNA molecules

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

Multiplexed, universal probe-based rare variant detection with USE-PCR

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Primate evolution of the recombination regulator PRDM9

Erratum: Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

Colloidal lenses allow high-temperature single-molecule imaging and improve fluorophore photostability

Accurate gene synthesis with tag-directed retrieval of sequence-verified DNA molecules

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

Multiplexed, universal probe-based rare variant detection with USE-PCR

Search

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