Nature Search

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Solvent exposure of specific nuclei of angiotensin II determined by NMR solvent saturation method

T. PHIL PITNER
JERRY D. GLICKSON
GARLAND R. MARSHALL
Research01 Aug 1974
Nature

Volume: 250, P: 582-584
Refining the telomere-telomerase hypothesis of aging and cancer

Shawn E. Holt
Jerry W. Shay
Woodring E. Wright
Reviews01 Jul 1996
Nature Biotechnology

Volume: 14, P: 836-839
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee
Jeffrey T. Laydon
Peter R. Young
Research29 Dec 1994
Nature

Volume: 372, P: 739-746
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy

Ginhoux and colleagues perform multi-omic characterization of hepatocellular carcinoma and identify an onco-fetal niche that includes fibroblasts, macrophages and endothelial cells and influences immunotherapy response and relapse.

Ziyi Li
Rhea Pai
Ankur Sharma
Research02 Jan 2024
Nature Cancer

Volume: 5, P: 167-186
Inhibition of human telomerase activity by peptide nucleic acids

James C. Norton
Mieczyslaw A. Piatyszek
David R. Corey
Research01 May 1996
Nature Biotechnology

Volume: 14, P: 615-619
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis

The molecular mechanisms underlying lymph-node metastasis in head and neck squamous-cell carcinoma remain to be investigated. Here, the authors perform single-cell RNA sequencing of cancer cells and CD8 + T cells and suggest potential mechanisms of immune evasion during early metastasis.

Hong Sheng Quah
Elaine Yiqun Cao
N. Gopalakrishna Iyer
ResearchOpen Access27 Mar 2023
Nature Communications

Volume: 14, P: 1-19
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse

Mehul T. Dattani
Juan-Pedro Martinez-Barbera
Iain C. A. F. Robinson
Research01 Jun 1998
Nature Genetics

Volume: 19, P: 125-133
Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation

The oligomeric Dam1 complex mediates microtubule attachment to kinetochores during mitosis; however, the significance of its oligomeric structure remains unclear. Umbreit et al. show that Dam1 oligomerization is required for microtubules to form attachments that are robust against tension.

Neil T. Umbreit
Matthew P. Miller
Trisha N. Davis
Research19 Sept 2014
Nature Communications

Volume: 5, P: 1-11
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

Analysis of peripheral mycobacteria-reactive CD4⁺ T cell receptor sequences from individuals infected with Mycobacterium tuberculosis shows a high degree of overlap between progressors and controllers, but points to some distinct clonotypes that are enriched in either group.

Munyaradzi Musvosvi
Huang Huang
Tran Van
ResearchOpen Access05 Jan 2023
Nature Medicine

Volume: 29, P: 258-269
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts

Lauren S Gollahon
Eliyahu Kraus
Michael A Tainsky
Research14 Aug 1998
Oncogene

Volume: 17, P: 709-717
A forward genetic screen identifies modifiers of rocaglate responsiveness

Leo Shen
Lauren Pugsley
Jerry Pelletier
ResearchOpen Access16 Sept 2021
Scientific Reports

Volume: 11, P: 1-13
Governing AI safety through independent audits

As highly automated systems become pervasive in society, enforceable governance principles are needed to ensure safe deployment. This Perspective proposes a pragmatic approach where independent audit of AI systems is central. The framework would embody three AAA governance principles: prospective risk Assessments, operation Audit trails and system Adherence to jurisdictional requirements.

Gregory Falco
Ben Shneiderman
Zee Kin Yeong
Reviews20 Jul 2021
Nature Machine Intelligence

Volume: 3, P: 566-571
Nanoscale molecular rectifiers

Molecular rectifiers are an essential component for the construction of molecular electronic devices, which are becoming potentially competitive with existing silicon-based devices. This Review provides an overview of molecular rectification and discusses the outlook for the field as well as prospects for commercialization.

Ritu Gupta
Jerry A. Fereiro
Prakash Chandra Mondal
Reviews13 Jan 2023
Nature Reviews Chemistry

Volume: 7, P: 106-122
Unveiling a new oceanic anoxic event at the Norian/Rhaetian boundary (Late Triassic)

Manuel Rigo
Xin Jin
Tetsuji Onoue
ResearchOpen Access06 Jul 2024
Scientific Reports

Volume: 14, P: 1-9
RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Adam Penn-Nicholson
Stanley Kimbung Mbandi
Lara Lewis
ResearchOpen Access25 May 2020
Scientific Reports

Volume: 10, P: 1-21
Maternal preconception circulating blood biomarker mixtures, child behavioural symptom scores and the potential mediating role of neonatal brain microstructure: the S-PRESTO cohort

Jian Huang
Ai Peng Tan
Jonathan Huang
ResearchOpen Access03 Feb 2023
Translational Psychiatry

Volume: 13, P: 1-9
A natural language fMRI dataset for voxelwise encoding models

Amanda LeBel
Lauren Wagner
Alexander G. Huth
ResearchOpen Access23 Aug 2023
Scientific Data

Volume: 10, P: 1-12
hTERT associates with human telomeres and enhances genomic stability and DNA repair

Girdhar G Sharma
Arun Gupta
Tej K Pandita
Research14 Jan 2003
Oncogene

Volume: 22, P: 131-146

Search

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Solvent exposure of specific nuclei of angiotensin II determined by NMR solvent saturation method

Refining the telomere-telomerase hypothesis of aging and cancer

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy

Inhibition of human telomerase activity by peptide nucleic acids

A second update on mapping the human genetic architecture of COVID-19

Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse

Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation

T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts

A forward genetic screen identifies modifiers of rocaglate responsiveness

Governing AI safety through independent audits

Nanoscale molecular rectifiers

Unveiling a new oceanic anoxic event at the Norian/Rhaetian boundary (Late Triassic)

RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Maternal preconception circulating blood biomarker mixtures, child behavioural symptom scores and the potential mediating role of neonatal brain microstructure: the S-PRESTO cohort

A natural language fMRI dataset for voxelwise encoding models

hTERT associates with human telomeres and enhances genomic stability and DNA repair

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