Nature Search

Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial

In people with HIV-1 undergoing antiretroviral treatment interruption, lefitolimod combined with broadly neutralizing antibodies (bNAbs) did not delay viral rebound beyond that achieved with bNAbs alone, raising the question of how to optimize combination immunotherapy to control HIV-1.

Jesper D. Gunst
Jesper F. Højen
Ole S. Søgaard
ResearchOpen Access11 Sept 2023
Nature Medicine

Volume: 29, P: 2547-2558
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise

In Greenlandic Inuit, a TBC1D4 loss-of-function mutation increases type 2 diabetes risk by tenfold. Carriers show severe muscle insulin resistance, impaired glucose disposal and reduced muscle GLUT4, yet exercise mitigates these defects, offering potential for personalized lifestyle interventions.

Jonas M. Kristensen
Rasmus Kjøbsted
Jørgen F. P. Wojtaszewski
ResearchOpen Access31 Oct 2024
Nature Metabolism

Volume: 6, P: 2254-2266
The structural basis of calcium transport by the calcium pump

In plants and fungi, cellular ion homeostasis is powered by the proton pump, a member of the P-type ATPase family. The first X-ray structure of the H⁺-ATPase is presented, and insight into the mechanism by which protons are transported against an electrochemical gradient is provided

Claus Olesen
Martin Picard
Poul Nissen
Research13 Dec 2007
Nature

Volume: 450, P: 1036-1042
Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

The results of genome-wide association studies are combined with quantitative interaction proteomics to narrow down the list of putative causal disease genes and filter modest association signals.

Alicia Lundby
Elizabeth J Rossin
Jesper V Olsen
Research22 Jun 2014
Nature Methods

Volume: 11, P: 868-874
Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

Common genetic variants in structural proteins contribute to risk of atrial fibrillation (AF). Here, using whole-exome sequencing, the authors identify rare truncating variants in TTN that associate with familial and early-onset AF and show defects in cardiac sarcomere assembly in ttn.2-mutant zebrafish.

Gustav Ahlberg
Lena Refsgaard
Morten S. Olesen
ResearchOpen Access17 Oct 2018
Nature Communications

Volume: 9, P: 1-11
Next-generation sequencing of AV nodal reentrant tachycardia patients identifies broad spectrum of variants in ion channel genes

Laura Andreasen
Gustav Ahlberg
Jesper H. Svendsen
Research02 Feb 2018
European Journal of Human Genetics

Volume: 26, P: 660-668
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8⁺ T cell immunity

Broadly neutralising anti-HIV-1 antibody (bNAb) administration in nonhuman primates has been shown to stimulate adaptive T cell-specific immunity, with infection prevention observed. In this work, the authors longitudinally analyse HIV-1 specific cellular immunity in HIV-1- infected individuals starting ART with or without adjunctive bNAb treatment.

Miriam Rosás-Umbert
Jesper D. Gunst
Ole S. Søgaard
ResearchOpen Access29 Oct 2022
Nature Communications

Volume: 13, P: 1-12
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

Coupling cure interventions with ART during early HIV infection may accelerate virus clearance and enhance T cell responses, supporting tailoring of monoclonal antibodies to sensitive viruses to improve their effects.

Jesper D. Gunst
Marie H. Pahus
Ole S. Søgaard
Research17 Oct 2022
Nature Medicine

Volume: 28, P: 2424-2435
Atrial fibrillation: the role of common and rare genetic variants

Morten S Olesen
Morten W Nielsen
Jesper H Svendsen
Reviews10 Jul 2013
European Journal of Human Genetics

Volume: 22, P: 297-306
The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm

An X-ray crystal structure of sarcoplasmic reticulum Ca²⁺-ATPase (SERCA) in the presence of sarcolipin, a SERCA regulator, is presented; the structure shows that sarcolipin traps SERCA in a previously unidentified ‘open’ state in which its high-affinity Ca²⁺-binding sites are unoccupied, but accessible from the cytoplasm.

Anne-Marie L. Winther
Maike Bublitz
Morten J. Buch-Pedersen
Research03 Mar 2013
Nature

Volume: 495, P: 265-269
Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes

The detailed interactions of membrane proteins with their lipid environment are poorly understood. Sonntaget al. use low-resolution X-ray crystallographic data and molecular dynamics simulations to study the manner in which the sarcoendoplasmic reticulum Ca²⁺–ATPase adapts to different membrane environments.

Yonathan Sonntag
Maria Musgaard
Lea Thøgersen
Research10 May 2011
Nature Communications

Volume: 2, P: 1-7
Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis

Laura Andreasen
Litten Bertelsen
Morten S. Olesen
ResearchOpen Access22 Jun 2020
Scientific Reports

Volume: 10, P: 1-8
Brugada syndrome risk loci seem protective against atrial fibrillation

Laura Andreasen
Jonas B Nielsen
Morten S Olesen
Research26 Mar 2014
European Journal of Human Genetics

Volume: 22, P: 1357-1361
Multi-ethnic genome-wide association study for atrial fibrillation

This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation. These loci are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.

Carolina Roselli
Mark D. Chaffin
Patrick T. Ellinor
Research11 Jun 2018
Nature Genetics

Volume: 50, P: 1225-1233
The impact of climate change on crop mix shift in the Nordic region

Doan Nainggolan
Abrha Teklay Abay
Mette Termansen
ResearchOpen Access20 Feb 2023
Scientific Reports

Volume: 13, P: 1-10
Use of sildenafil or other phosphodiesterase inhibitors and risk of melanoma

Anton Pottegård
Sigrún Alba Johannesdottir Schmidt
Laurel A Habel
ResearchOpen Access16 Aug 2016
British Journal of Cancer

Volume: 115, P: 895-900
Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts

Christian Paludan-Müller
Jonas Ghouse
Morten S. Olesen
Research01 May 2019
European Journal of Human Genetics

Volume: 27, P: 1427-1435
Numerous Brugada syndrome–associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality

Jonas Ghouse
Christian T. Have
Morten S. Olesen
Research06 Oct 2016
Genetics in Medicine

Volume: 19, P: 521-528
New population-based exome data are questioning the pathogenicity of previously cardiomyopathy-associated genetic variants

Charlotte Andreasen
Jonas B Nielsen
Morten S Olesen
ResearchOpen Access09 Jan 2013
European Journal of Human Genetics

Volume: 21, P: 918-928
Effects of limiting digital screen use on well-being, mood, and biomarkers of stress in adults

Jesper Pedersen
Martin Gillies Banke Rasmussen
Anders Grøntved
ResearchOpen Access12 Oct 2022
npj Mental Health Research

Volume: 1, P: 1-10
A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation

Thea Hyttel Hansen
Yannan Yan
Nicole Schmitt
ResearchOpen Access29 Jan 2020
Scientific Reports

Volume: 10, P: 1-10
Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study

Mette Reilev
Jesper Lykkegaard
Anton Pottegård
ResearchOpen Access17 Apr 2017
npj Primary Care Respiratory Medicine

Volume: 27, P: 1-6
Gel chromatography and analytical ultracentrifugation to determine the extent of detergent binding and aggregation, and Stokes radius of membrane proteins using sarcoplasmic reticulum Ca²⁺–ATPase as an example

Marc le Maire
Bertrand Arnou
Jesper V Møller
Protocols30 Oct 2008
Nature Protocols

Volume: 3, P: 1782-1795
Long-term use of lithium and risk of colorectal adenocarcinoma: a nationwide case–control study

Anton Pottegård
Zandra Nymand Ennis
Søren Friis
ResearchOpen Access11 Feb 2016
British Journal of Cancer

Volume: 114, P: 571-575
Septins are critical regulators of osteoclastic bone resorption

Anaïs M. J. Møller
Ernst-Martin Füchtbauer
Kent Søe
ResearchOpen Access29 Aug 2018
Scientific Reports

Volume: 8, P: 1-15

Search

Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial

Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise

The structural basis of calcium transport by the calcium pump

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

Next-generation sequencing of AV nodal reentrant tachycardia patients identifies broad spectrum of variants in ion channel genes

Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8⁺ T cell immunity

Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

Atrial fibrillation: the role of common and rare genetic variants

The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm

Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes

Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis

Brugada syndrome risk loci seem protective against atrial fibrillation

Multi-ethnic genome-wide association study for atrial fibrillation

The impact of climate change on crop mix shift in the Nordic region

Use of sildenafil or other phosphodiesterase inhibitors and risk of melanoma

Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts

Numerous Brugada syndrome–associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality

New population-based exome data are questioning the pathogenicity of previously cardiomyopathy-associated genetic variants

Effects of limiting digital screen use on well-being, mood, and biomarkers of stress in adults

A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation

Stability of the frequent COPD exacerbator in the general population: A Danish nationwide register-based study

Gel chromatography and analytical ultracentrifugation to determine the extent of detergent binding and aggregation, and Stokes radius of membrane proteins using sarcoplasmic reticulum Ca²⁺–ATPase as an example

Long-term use of lithium and risk of colorectal adenocarcinoma: a nationwide case–control study

Septins are critical regulators of osteoclastic bone resorption

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