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Showing 1–3 of 3 results
Advanced filters: Author: Jessamy C. Tiffen Clear advanced filters

  • David Adams, Julia Newton-Bishop, Timothy Bishop, Nicholas Hayward and colleagues identify loss-of-function variants in POT1 in several families with early onset multiple primary melanoma. They further show that these variants disrupt telomere binding by POT1 and are associated with increased telomere length.

    • Carla Daniela Robles-Espinoza
    • Mark Harland
    • David J Adams
    Research
    Nature Genetics
    Volume: 46, P: 478-481

  • David Adams and colleagues identify inactivating mutations in CUX1 in diverse human cancers. They validate CUX1 as a tumor suppressor using mouse and Drosophila cancer models, and show that CUX1 deficiency activates phosphoinositide 3-kinase signaling through transcriptional downregulation of a PI3K inhibitor.

    • Chi C Wong
    • Inigo Martincorena
    • David J Adams
    Research
    Nature Genetics
    Volume: 46, P: 33-38