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Showing 1–4 of 4 results
Advanced filters: Author: Jesse D. Armitage Clear advanced filters

  • A CRISPR knock-in strategy that uses endogenous gene regulatory mechanisms can engineer ‘armoured’ CAR T cells that secrete proinflammatory cytokines directly within a tumour without causing toxicity, leading to prolonged survival in mice.

    • Amanda X. Y. Chen
    • Kah Min Yap
    • Paul A. Beavis
    ResearchOpen Access
    Nature
    Volume: 644, P: 241-251

  • A study of 17,152 patients with cancer identified pathogenic germline variants in cancer predisposition genes. Although tumors showed biallelic inactivation for high-penetrance genes, this was not the case in most patients with pathogenic variants in low-penetrance genes, suggesting alternative routes to tumorigenesis.

    • Preethi Srinivasan
    • Chaitanya Bandlamudi
    • Barry S. Taylor
    Research
    Nature Genetics
    Volume: 53, P: 1577-1585

  • As phase 1 of the Earth Microbiome Project, analysis of 16S ribosomal RNA sequences from more than 27,000 environmental samples delivers a global picture of the basic structure and drivers of microbial distribution.

    • Luke R. Thompson
    • Jon G. Sanders
    • Hongxia Zhao
    ResearchOpen Access
    Nature
    Volume: 551, P: 457-463