A set of genes that cause lethality when mutated in polyploid cells, but not when mutated in wild-type cells, are involved in cell cycle processes, such as homologous recombination and kinetochore attachment to the spindle. As many cancer cells exhibit polyploidy, targeting these genes may be an effective strategy to fight cancer.
- Zuzana Storchová
- Amanda Breneman
- David Pellman
