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Showing 1–5 of 5 results
Advanced filters: Author: Jessica Rusert Clear advanced filters

  • Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors.

    • Catherine Lee
    • Vasilisa A. Rudneva
    • Robert J. Wechsler-Reya
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Medulloblastomas lacking p53 do not express surface class I major histocompatibility complex (MHC-I) and are resistant to immune rejection. Tumor necrosis factor rescues MHC-I expression and synergizes with immune checkpoint inhibitors to promote rejection.

    • Alexandra Garancher
    • Hiromichi Suzuki
    • Robert J. Wechsler-Reya
    Research
    Nature Neuroscience
    Volume: 23, P: 842-853

  • Circular extrachromosomal DNA is found in nearly half of human cancers of a wide variety of histologic types, increasing the copy number of driver oncogenes and intratumoral heterogeneity more effectively than chromosomal amplification and contributing to tumor evolution.

    • Kristen M. Turner
    • Viraj Deshpande
    • Paul S. Mischel
    Research
    Nature
    Volume: 543, P: 122-125