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Laboratory validation of a clinical metagenomic next-generation sequencing assay for respiratory virus detection and discovery

Metagenomic next-generation sequencing has the potential to support diagnosis of unknown infections as it can identify all potential pathogens without requiring a prior suspected cause. Here, the authors develop and clinically validate a metagenomics-based assay for common and novel respiratory viral pathogens.

Jessica Karielle Tan
Venice Servellita
Charles Y. Chiu
ResearchOpen Access12 Nov 2024
Nature Communications

Volume: 15, P: 1-16
CRISPR–Cas12-based detection of SARS-CoV-2

SARS-CoV-2 in patient samples is detected in under an hour using a CRISPR-based lateral flow assay.

James P. Broughton
Xianding Deng
Charles Y. Chiu
Research16 Apr 2020
Nature Biotechnology

Volume: 38, P: 870-874
Seven-year performance of a clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections

Next-generation metagenomic testing increases the accuracy and sensitivity of the etiology of central nervous system infections in hospitalized patients.

Patrick Benoit
Noah Brazer
Charles Y. Chiu
ResearchOpen Access12 Nov 2024
Nature Medicine

Volume: 30, P: 3522-3533
Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California

A combined analysis of SARS-CoV-2 viral load and whole-genome sequences from COVID-19 patients, including some who were previously vaccinated, reveals that vaccine breakthrough infections are more commonly associated with antibody-resistant SARS-CoV-2 variants than infections in unvaccinated individuals, and that symptomatic breakthrough infections may be as efficient in spreading COVID-19 as unvaccinated infections.

Venice Servellita
Mary Kate Morris
Charles Y. Chiu
Research10 Jan 2022
Nature Microbiology

Volume: 7, P: 277-288
Differentiation enhances Zika virus infection of neuronal brain cells

Claudia Sánchez-San Martín
Tony Li
Charles Y. Chiu
ResearchOpen Access28 Sept 2018
Scientific Reports

Volume: 8, P: 1-10

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Laboratory validation of a clinical metagenomic next-generation sequencing assay for respiratory virus detection and discovery

CRISPR–Cas12-based detection of SARS-CoV-2

Seven-year performance of a clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections

Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California

Differentiation enhances Zika virus infection of neuronal brain cells

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