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Nature Immunology (2)
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The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells

The role of the unfolded protein response in the immune system is poorly understood. Lambrecht and colleagues show that CD8α⁺ DCs have a constitutively active component of this response that is important for their homeostatic function.

Fabiola Osorio
Simon J Tavernier
Bart N Lambrecht
Research19 Jan 2014
Nature Immunology

Volume: 15, P: 248-257
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

Tavernier et al. show that loss of the protective IRE1–XBP1 stress sensor results in the death of conventional dendritic cells in the lung, whereas those in the intestine survive due to a stronger ATF4-dependent stress response and RIDD activation.

Simon J. Tavernier
Fabiola Osorio
Sophie Janssens
Research01 May 2017
Nature Cell Biology

Volume: 19, P: 698-710
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

van Loo and colleagues provide insights into the action of the anti-inflammatory protein A20. The ZnF7 and ZnF4 ubiquitin-binding domains of A20 are both required to suppress inflammatory signaling and cell death; however, these zinc fingers operate via distinct mechanisms.

Arne Martens
Dario Priem
Geert van Loo
Research16 Mar 2020
Nature Immunology

Volume: 21, P: 381-387