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Showing 1–3 of 3 results
Advanced filters: Author: Jessica Viscomi Clear advanced filters

  • A study of dependencies associated with cancer-causing mutations has identified a small molecule that binds to SHOC2 and inhibits RAS signalling in cells carrying NRAS Q61 mutations, a common oncogenic driver in melanoma.

    • Zachary J. Hauseman
    • Frédéric Stauffer
    • Luca Tordella
    ResearchOpen Access
    Nature
    Volume: 642, P: 232-241

  • A structure of the MRAS–SHOC2–PP1C complex supports a RAS-driven and multi-molecular model for RAF activation in which individual RAS–GTP molecules recruit RAF–14-3-3 and SHOC2–PP1C to activate the downstream pathway.

    • Zachary J. Hauseman
    • Michelle Fodor
    • Daniel A. King
    ResearchOpen Access
    Nature
    Volume: 609, P: 416-423