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Activation of lysophagy by a TBK1-SCF^FBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage

Damaged lysosomes are eliminated by lysophagy, yet the regulatory mechanisms of this process are not fully defined. Here, the authors identify that the TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis is essential for lysosome degradation, with FBXO3 functioning in lysosome integrity.

Na Yeon Park
Doo Sin Jo
Dong-Hyung Cho
ResearchOpen Access28 Jan 2025
Nature Communications

Volume: 16, P: 1-15
Factors affecting visual outcome in patients with toxic optic neuropathy caused by ethambutol

Kwang Eon Han
Heejin Yoon
Su-Jin Kim
ResearchOpen Access20 Feb 2025
Scientific Reports

Volume: 15, P: 1-7
Optical separation of mechanical strain from charge doping in graphene

The spectral position of Raman peaks is a useful diagnostic for determining the degree of strain and excess electronic charges present in graphene. This study demonstrates that these two contributions can be separated from each other and therefore be obtained at the same time.

Ji Eun Lee
Gwanghyun Ahn
Sunmin Ryu
Research28 Aug 2012
Nature Communications

Volume: 3, P: 1-8
Menin represses JunD transcriptional activity in protein kinase Cθ-mediated Nur77 expression

Hyungsoo Kim
Ji-Eun Lee
Hong-Duk Youn
ResearchOpen Access01 Oct 2005
Experimental & Molecular Medicine

Volume: 37, P: 466-475
Development of a machine learning model to identify intraventricular hemorrhage using time-series analysis in preterm infants

Hye-Ji Han
Hyunmin Ji
Young Hwa Jung
ResearchOpen Access10 Oct 2024
Scientific Reports

Volume: 14, P: 1-8
Torsion and clinical features in patients with acquired fourth cranial nerve palsy

Heeyoung Choi
Sang Yoon Kim
Ji-Eun Lee
ResearchOpen Access27 Mar 2024
Scientific Reports

Volume: 14, P: 1-6
Self-cleanable, waterproof, transparent, and flexible Ag networks covered by hydrophobic polytetrafluoroethylene for multi-functional flexible thin film heaters

Ji-Eun Lee
Han-Ki Kim
ResearchOpen Access13 Nov 2019
Scientific Reports

Volume: 9, P: 1-11
Vascular differentiation of multipotent spermatogonial stem cells derived from neonatal mouse testis

Ji-Eun Im
Sun-Hwa Song
Wonhee Suh
ResearchOpen Access19 Jan 2012
Experimental & Molecular Medicine

Volume: 44, P: 303-309
Binocular function in patients with intermittent exotropia accompanied by unilateral congenital ptosis

Hee-young Choi
Su-Jin Kim
Ji-Eun Lee
ResearchOpen Access31 Oct 2022
Scientific Reports

Volume: 12, P: 1-6
Comparison of vision-related quality of life in patients with homonymous hemianopia and monocular blindness

Hee-young Choi
Su-Jin Kim
Ji-Eun Lee
ResearchOpen Access21 Apr 2022
Scientific Reports

Volume: 12, P: 1-7
Role of Co-Vapors in Vapor Deposition Polymerization

Ji Eun Lee
Younghee Lee
Hyeonseok Yoon
ResearchOpen Access12 Feb 2015
Scientific Reports

Volume: 5, P: 1-8
Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

Kim and colleagues and Kwon and colleagues reveal that amino-terminal arginylation of BiP promotes its targeting to autophagy adaptor p62 and subsequent lysosomal degradation of BiP, p62 and associated cargo.

Hyunjoo Cha-Molstad
Ki Sa Sung
Yong Tae Kwon
Research15 Jun 2015
Nature Cell Biology

Volume: 17, P: 917-929
Gut commensal Kineothrix alysoides mitigates liver dysfunction by restoring lipid metabolism and gut microbial balance

Kyoung Jin Choi
Mi Young Yoon
Sang Sun Yoon
ResearchOpen Access06 Sept 2023
Scientific Reports

Volume: 13, P: 1-13
Lactobacillus paracasei-derived extracellular vesicles reverse molecular and behavioral deficits in mouse models of autism spectrum disorder

Jin-Young Park
Eun-Hwa Lee
Pyung-Lim Han
ResearchOpen Access01 Apr 2025
Experimental & Molecular Medicine

Volume: 57, P: 788-803
Tumour-associated myeloid cells expressing IL-10R2/IL-22R1 as a potential biomarker for diagnosis and recurrence of pancreatic ductal adenocarcinoma

Hyung Keun Lee
So Young Kim
Dong Ki Lee
ResearchOpen Access20 Apr 2024
British Journal of Cancer

Volume: 130, P: 1979-1989
Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia

Ji-Eun Park
Hye-Bin Lee
Ho-Young Park
ResearchOpen Access06 Feb 2025
npj Science of Food

Volume: 9, P: 1-12
Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways

Bongkun Choi
Ji-Eun Kim
Eun-Ju Chang
ResearchOpen Access22 Apr 2022
International Journal of Oral Science

Volume: 14, P: 1-9
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1

Hye-Kyung Park
Nam Gu Yoon
Byoung Heon Kang
ResearchOpen Access20 Jan 2020
Experimental & Molecular Medicine

Volume: 52, P: 79-91
Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

Kang, Park and colleagues develop and demonstrate the effects of a new drug candidate for treatment of Hutchinson-Gilford progeria syndrome pathologies. Progerinin extends the life span of mice used to model this disease and induces histological and physiological improvements.

So-mi Kang
Min-Ho Yoon
Bum-Joon Park
ResearchOpen Access04 Jan 2021
Communications Biology

Volume: 4, P: 1-11
The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade

Hong-Nhung Tran
Quy-Hoai Nguyen
Yongsu Jeong
Research20 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1563-1574
Differential diagnosis of common etiologies of left ventricular hypertrophy using a hybrid CNN-LSTM model

In-Chang Hwang
Dongjun Choi
Goo-Yeong Cho
ResearchOpen Access05 Dec 2022
Scientific Reports

Volume: 12, P: 1-12
Automated in-depth cerebral arterial labelling using cerebrovascular vasculature reframing and deep neural networks

Suk-Woo Hong
Ha-Na Song
Woo-Keun Seo
ResearchOpen Access24 Feb 2023
Scientific Reports

Volume: 13, P: 1-14
CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice

Hwa Seon Koo
Min-Ji Yoon
Youn-Jung Kang
ResearchOpen Access01 Apr 2021
Scientific Reports

Volume: 11, P: 1-16
Impact of BMI on peak growth hormone responses to provocative tests and therapeutic outcome in children with growth hormone deficiency

Aram Yang
Sung Yoon Cho
Ji-Eun Lee
ResearchOpen Access07 Nov 2019
Scientific Reports

Volume: 9, P: 1-10
Human dopamine receptor nanovesicles for gate-potential modulators in high-performance field-effect transistor biosensors

Seon Joo Park
Hyun Seok Song
Jyongsik Jang
ResearchOpen Access11 Mar 2014
Scientific Reports

Volume: 4, P: 1-8
Inhibition of highly pathogenic avian influenza (HPAI) virus by a peptide derived from vFLIP through its direct destabilization of viruses

Ho-Jin Moon
Chamilani Nikapitiya
Jong-Soo Lee
ResearchOpen Access07 Jul 2017
Scientific Reports

Volume: 7, P: 1-11
Author Correction: Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

So-mi Kang
Min-Ho Yoon
Bum-Joon Park
Amendments and CorrectionsOpen Access02 Mar 2021
Communications Biology

Volume: 4, P: 1
PELI1 expression is correlated with MYC and BCL6 expression and associated with poor prognosis in diffuse large B-cell lymphoma

Ji-Young Choe
Mira Park
Ji Eun Kim
Research29 Jul 2016
Modern Pathology

Volume: 29, P: 1313-1323
Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction

Hye Sook Min
Jung Eun Kim
Dae Ryong Cha
Research31 Mar 2014
Laboratory Investigation

Volume: 94, P: 598-607
Resistance to Fas-mediated apoptosis is restored by cycloheximide through the downregulation of cellular FLIP_L in NK/T-cell lymphoma

Yoon Kyung Jeon
Heejung Kim
Chul-Woo Kim
Research16 May 2005
Laboratory Investigation

Volume: 85, P: 874-884
Mechanical compression induces VEGFA overexpression in breast cancer via DNMT3A-dependent miR-9 downregulation

Baek Gil Kim
Ming-Qing Gao
Nam Hoon Cho
ResearchOpen Access02 Mar 2017
Cell Death & Disease

Volume: 8, P: e2646
Significant increase in the water dispersibility of zinc phthalocyanine nanowires and applications in cancer phototherapy

Water-dispersed nanowires for phototherapy: Without passivation of any water-friendly functional groups in its backbone, one-dimensional zinc phthalocyanine nanowires show remarkably increased dispersibility in water. Upon irradiation with near infrared light, the zinc phthalocyanine nanowires exhibit dual photodynamic and photothermal properties, which enhance the cytotoxic efficiency against tumor cells.

Hye Kyung Moon
Minhyeok Son
Hee Cheul Choi
ResearchOpen Access13 Apr 2012
NPG Asia Materials

Volume: 4, P: e12

Search

Activation of lysophagy by a TBK1-SCF^FBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage

Factors affecting visual outcome in patients with toxic optic neuropathy caused by ethambutol

Optical separation of mechanical strain from charge doping in graphene

Menin represses JunD transcriptional activity in protein kinase Cθ-mediated Nur77 expression

Development of a machine learning model to identify intraventricular hemorrhage using time-series analysis in preterm infants

Torsion and clinical features in patients with acquired fourth cranial nerve palsy

Self-cleanable, waterproof, transparent, and flexible Ag networks covered by hydrophobic polytetrafluoroethylene for multi-functional flexible thin film heaters

Vascular differentiation of multipotent spermatogonial stem cells derived from neonatal mouse testis

Binocular function in patients with intermittent exotropia accompanied by unilateral congenital ptosis

Comparison of vision-related quality of life in patients with homonymous hemianopia and monocular blindness

Role of Co-Vapors in Vapor Deposition Polymerization

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

Gut commensal Kineothrix alysoides mitigates liver dysfunction by restoring lipid metabolism and gut microbial balance

Lactobacillus paracasei-derived extracellular vesicles reverse molecular and behavioral deficits in mouse models of autism spectrum disorder

Tumour-associated myeloid cells expressing IL-10R2/IL-22R1 as a potential biomarker for diagnosis and recurrence of pancreatic ductal adenocarcinoma

Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia

Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1

Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade

Differential diagnosis of common etiologies of left ventricular hypertrophy using a hybrid CNN-LSTM model

Automated in-depth cerebral arterial labelling using cerebrovascular vasculature reframing and deep neural networks

CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice

Impact of BMI on peak growth hormone responses to provocative tests and therapeutic outcome in children with growth hormone deficiency

Human dopamine receptor nanovesicles for gate-potential modulators in high-performance field-effect transistor biosensors

Inhibition of highly pathogenic avian influenza (HPAI) virus by a peptide derived from vFLIP through its direct destabilization of viruses

Author Correction: Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

PELI1 expression is correlated with MYC and BCL6 expression and associated with poor prognosis in diffuse large B-cell lymphoma

Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction

Resistance to Fas-mediated apoptosis is restored by cycloheximide through the downregulation of cellular FLIP_L in NK/T-cell lymphoma

Mechanical compression induces VEGFA overexpression in breast cancer via DNMT3A-dependent miR-9 downregulation

Significant increase in the water dispersibility of zinc phthalocyanine nanowires and applications in cancer phototherapy

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