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Showing 1–10 of 10 results
Advanced filters: Author: Jian Carrot-Zhang Clear advanced filters

  • The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration.

    • Haiquan Chen
    • Jian Carrot-Zhang
    • Matthew Meyerson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-6

  • Twelve early career investigators share experiences from the process of starting their laboratories throughout the past year, and reflect on the challenges faced and the opportunities seized.

    • Mautin Barry-Hundeyin
    • Jian Carrot-Zhang
    • Ying Zhang
    Reviews
    Nature Cancer
    Volume: 3, P: 1426-1431

  • Analysis of pan-cancer clinical genomic sequencing finds that body mass index associates with driver mutations in certain cancer types, including most prominently lung adenocarcinoma. Obesity may thus influence tumor genetics.

    • Cerise Tang
    • Venise Jan Castillon
    • Ed Reznik
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 2318-2321

  • A study generates a clinicogenomics dataset resource, MSK-CHORD, that combines natural language processing-derived clinical annotations with patient medical data from various sources to improve models of cancer outcome.

    • Justin Jee
    • Christopher Fong
    • Xinran Bi
    ResearchOpen Access
    Nature
    Volume: 636, P: 728-736

  • It is known that invasive lung adenocarcinomas evolve from pre-cancerous dysplastic lesions. In this study, the authors show that evolution of pre-cancerous lesions is accompanied by DNA methylation alterations, and that global hypomethylation correlates with immune infiltration, mutational burden and copy number alterations.

    • Xin Hu
    • Marcos R. Estecio
    • Jianjun Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • William Foulkes and colleagues identify germline inactivating mutations in familial cases of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Through additional analysis of non-familial tumors, the authors find that nearly 100% of tumors carry SMARCA4 mutations and 38 of 40 lack protein expression, implicating SMARCA4 loss as the major cause of SCCOHT.

    • Leora Witkowski
    • Jian Carrot-Zhang
    • William D Foulkes
    Research
    Nature Genetics
    Volume: 46, P: 438-443

  • Mohammad Akbari and colleagues report that rare truncating mutations in RECQL are associated with breast cancer susceptibility. RECQL encodes a helicase that helps prevent double-stranded DNA breaks by stabilizing stalled or regressed replication forks.

    • Cezary Cybulski
    • Jian Carrot-Zhang
    • Mohammad R Akbari
    Research
    Nature Genetics
    Volume: 47, P: 643-646