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Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster

Mitochondrial dynamics change during ageing, with larger mitochondria and altered protein import in older animals. Here the authors show that Dosmit protein mediates mitochondrial morphology with Rab32 by inducing double-membraned vesicles that regulate protein trafficking into mitochondria.

Po-Lin Chen
Kai-Ting Huang
Chun-Hong Chen
ResearchOpen Access22 May 2020
Nature Communications

Volume: 11, P: 1-19
Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction

Studies on Drosophila BCAA-catabolism mutants reveal disrupted coordination between AMPK, PP2Ac, and mitochondrial function in brain tissues, uncovering a pivotal mechanism linking metabolic dysfunction to neuronal damage.

Shih-Cheng Wu
Yan-Jhen Chen
Chun-Hong Chen
ResearchOpen Access21 Jan 2025
Communications Biology

Volume: 8, P: 1-17
Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain

Yen-Wei Lai
Sao-Yu Chu
Hung-Hsiang Yu
ResearchOpen Access20 Mar 2020
Scientific Reports

Volume: 10, P: 1-7
Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor

Yen-Wei Lai
Sao-Yu Chu
Hung-Hsiang Yu
ResearchOpen Access23 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Author Correction: Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

Wei-Liang Liu
Chia-Wei Hsu
Chun-Hong Chen
Amendments and CorrectionsOpen Access10 Jan 2022
Scientific Reports

Volume: 12, P: 1
miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer’s model

Prajakta Deshpande
Chao-Yi Chen
Amit Singh
ResearchOpen Access18 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-17
Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

Wei-Liang Liu
Chia-Wei Hsu
Chun-Hong Chen
ResearchOpen Access13 Dec 2021
Scientific Reports

Volume: 11, P: 1-16
Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy

Xing Sun
Yongjia Duan
Yanshan Fang
ResearchOpen Access20 Sept 2018
Cell Death & Disease

Volume: 9, P: 1-16
Assessing the cognitive status of Drosophila by the value-based feeding decision

Chih-Chieh Yu
Ferng-Chang Chang
Chih-Fei Kao
ResearchOpen Access15 Sept 2021
npj Aging and Mechanisms of Disease

Volume: 7, P: 1-11
Synthetic miRNAs induce dual arboviral-resistance phenotypes in the vector mosquito Aedes aegypti

Pei-Shi Yen et al. report a strategy for engineering transgenic Aedes aegypti mosquitoes to express antiviral miRNAs that simultaneously target two distinct arboviruses, dengue and chikungunya. The strategy results in reduced viral transmission in the mosquito saliva following an infected bloodmeal.

Pei-Shi Yen
Anthony James
Anna-Bella Failloux
ResearchOpen Access08 Feb 2018
Communications Biology

Volume: 1, P: 1-9
Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1

Wei Liu
Xiuying Duan
Chao Tong
Research06 Jan 2020
Cell Death & Differentiation

Volume: 27, P: 2014-2029

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Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster

Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction

Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain

Drosophila microRNA-34 Impairs Axon Pruning of Mushroom Body γ Neurons by Downregulating the Expression of Ecdysone Receptor

Author Correction: Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer’s model

Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy

Assessing the cognitive status of Drosophila by the value-based feeding decision

Synthetic miRNAs induce dual arboviral-resistance phenotypes in the vector mosquito Aedes aegypti

Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1

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