Nature Search

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Jianxin Shi
Kouya Shiraishi
Qing Lan
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-17
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Hereditary pancreatitis caused by triplication of the trypsinogen locus

Cédric Le Maréchal
Emmanuelle Masson
Claude Férec
Research29 Oct 2006
Nature Genetics

Volume: 38, P: 1372-1374
Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study

Shang-lin Zhou
Hong-yuan Chu
Xue-chu Zhen
Research26 May 2014
Acta Pharmacologica Sinica

Volume: 35, P: 738-751
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

A cross-ancestry genome-wide association meta-analysis of lung cancer including 61,047 cases and 947,237 controls identifies five new cross-ancestry susceptibility loci and highlights ancestry-specific effects of common and rare variants on lung cancer risk.

Jinyoung Byun
Younghun Han
Christopher I. Amos
Research01 Aug 2022
Nature Genetics

Volume: 54, P: 1167-1177
Natural persistence of the coastal plant Glehnia littoralis along temperate sandy coasts

Hong-Xiao Yang
Jian-Min Chu
Xiao-Shan Liu
ResearchOpen Access17 Feb 2017
Scientific Reports

Volume: 7, P: 1-7
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology.

Xuemei Ji
Yohan Bossé
Christopher I. Amos
ResearchOpen Access13 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

The basis for associations between lung cancer and major histocompatibility complex genes is not completely understood. Here the authors further consider genetic variation within the MHC region in lung cancer patients and identify independent associations within HLA genes that explain MHC lung cancer associations in Europeans and Asian populations.

Aida Ferreiro-Iglesias
Corina Lesseur
Paul Brennan
ResearchOpen Access25 Sept 2018
Nature Communications

Volume: 9, P: 1-12
The blood proteome of imminent lung cancer diagnosis

Lung cancer screening could enhance early diagnosis and treatment. Here, the authors used proteomic analysis of pre-diagnosis samples across 6 cohorts to identify 36 proteins associated with imminent lung cancer diagnosis.

Demetrius Albanes
Karine Alcala
Wei Zheng
ResearchOpen Access01 Jun 2023
Nature Communications

Volume: 14, P: 1-12
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Christopher Amos and colleagues perform genome-wide association analysis for lung cancer using cohorts genotyped on the OncoArray and combing these with existing data. They identify 18 loci, 10 of which are new, finding heterogeneity across the different lung cancer subtypes, and explore candidate genes through eQTL analysis in lung tissue.

James D McKay
Rayjean J Hung
Christopher I Amos
Research12 Jun 2017
Nature Genetics

Volume: 49, P: 1126-1132
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

Anders Molven and colleagues show that a recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. The hybrid allele is associated with approximately fivefold-higher risk of disease, and it encodes a protein with reduced lipolytic activity and prominent intracellular accumulation.

Karianne Fjeld
Frank Ulrich Weiss
Anders Molven
Research16 Mar 2015
Nature Genetics

Volume: 47, P: 518-522
Assessing the pathological relevance of SPINK1 promoter variants

Arnaud Boulling
Heiko Witt
Claude Férec
ResearchOpen Access25 May 2011
European Journal of Human Genetics

Volume: 19, P: 1066-1073
A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium

Øivind Midttun
Arve Ulvik
Per M. Ueland
ResearchOpen Access18 Jan 2023
Scientific Reports

Volume: 13, P: 1-13
Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults

Hana Zahed
Mattias Johansson
Hilary A. Robbins
ResearchOpen Access05 Jul 2021
Scientific Reports

Volume: 11, P: 1-13

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Polygenic prediction of body mass index and obesity through the life course and across ancestries

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

A saturated map of common genetic variants associated with human height

Hereditary pancreatitis caused by triplication of the trypsinogen locus

Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

Natural persistence of the coastal plant Glehnia littoralis along temperate sandy coasts

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

The blood proteome of imminent lung cancer diagnosis

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

Assessing the pathological relevance of SPINK1 promoter variants

A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium

Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults

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