A new autoinducer–receptor pair, 3,5-dimethylpyrazin-2-ol (DPO)–VqmA, acts in parallel to canonical Vibrio cholerae quorum-sensing pathways. Downstream of VqmA is the small RNA target VqmR, which, like DPO, represses genes required for biofilm formation and toxin production.
- Kai Papenfort
- Justin E Silpe
- Bonnie L Bassler