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Showing 1–16 of 16 results
Advanced filters: Author: Jianhan Chen Clear advanced filters

  • CaMKII is a key enzyme in brain, heart, and egg cells, regulated by calcium signals. Here, authors show that charged residues in the variable linker tune CaMKII activity, a mechanism that may underlie cell type–specific responses.

    • Bao V. Nguyen
    • Can Özden
    • Margaret M. Stratton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Designing energy efficient systems capable to directly process signals at biological voltages remains a challenge. Here, the authors propose a bio-compatible memristor device based on protein-nanowire dielectric, harvested from the bacterium Geobactor sulfurreducens, working at biological voltages.

    • Tianda Fu
    • Xiaomeng Liu
    • Jun Yao
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • HCN ion channels activate upon hyperpolarization, in contrast to other members of the voltage-gated ion channel superfamily. Here, authors reveal the structural basis of inverted voltage-dependence by solving the structures of this channel in Closed, Open and Intermediate conformations.

    • Verena Burtscher
    • Jonathan Mount
    • Baron Chanda
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • BK channels are regulated by membrane voltage and intracellular Ca2+ but the structural features that block the ion flow in the closed state remain unknown. Here authors use molecular dynamics simulation and show that a physical gate is not required; instead ion flow is regulated by hydrophobic dewetting due to changes in pore shape and surface hydrophobicity.

    • Zhiguang Jia
    • Mahdieh Yazdani
    • Jianhan Chen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • Epigallocatechin gallate (EGCG) is a catechin flavonoid which induces apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Here authors use an interdisciplinary approach to show a direct interaction between EGCG and the tumor suppressor p53 and demonstrate that EGCG inhibits ubiquitination of p53 by MDM2.

    • Jing Zhao
    • Alan Blayney
    • Chunyu Wang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • TMEM16F is an enigmatic Ca2 + -activated phospholipid scramblase (CaPLSase) that passively transports phospholipids. Here authors identify an inner activation gate and its disruption profoundly alters TMEM16F phospholipid permeation.

    • Trieu Le
    • Zhiguang Jia
    • Huanghe Yang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability and muscle contraction. Here authors show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desensitization via binding to a putative binding site.

    • Son C. Le
    • Zhiguang Jia
    • Huanghe Yang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • A new type of energy-harvesting device, based on protein nanowires from the microbe Geobacter sulforreducens, can generate a sustained power output by producing a moisture gradient across the nanowire film using natural humidity.

    • Xiaomeng Liu
    • Hongyan Gao
    • Jun Yao
    Research
    Nature
    Volume: 578, P: 550-554

  • NMR reveals the dynamic stretching ability of the subdomain LH of the intrinsically disordered p21, providing a physical basis for the binding and functional diversity in its cell cycle regulatory role as a modulator of Cdk–cyclin complexes.

    • Yuefeng Wang
    • John C Fisher
    • Richard W Kriwacki
    Research
    Nature Chemical Biology
    Volume: 7, P: 214-221

  • γ-glycidoxypropyltrimethoxysilane was used as a bridge between hydrophobic particles and polyurethane to prepare dual-repellent coating in aqueous environment. This coating demonstrates superior mechanical strength, antifouling properties, and self-cleaning capabilities. In comparison to the uncoated substrate, the amphiphobic coating exhibited a 9-minute delay in freezing time and a reduced adhesion strength of 17 kPa. These results highlight the promising potential of the PKF-SiO2 coating for enhancing antifouling and self-cleaning functionalities in various applications, including textiles and construction

    • Shuyang Xing
    • Xin Wang
    • Ruiyi Luo
    Research
    Polymer Journal
    Volume: 57, P: 1003-1013

  • Chen and Jia investigate the synergistic regulating role of Ca2+ binding and the signaling lipid PIP2 in TMEM16A channel gating. Their study is significant as it provides new insights into the activated state of TMEM16A and highlights an example of functional importance of lipids in regulating membrane-associated proteins.

    • Zhiguang Jia
    • Jianhan Chen
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-10

  • Atomistic simulations on TRPV4 reveals that hydrophobic gating and bundle-crossing mechanisms coexist in ion channels, highlighting the significance of understanding these mechanisms and shedding light on the regulation of ion flow in various biological channels.

    • Jian Huang
    • Jianhan Chen
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-9