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Engineering Cu to achieve high catalytic selectivity towards carbon monoxide at high current density is challenging. Here, the authors report an Cu-Sb single-atom alloy catalyst that catalyzes CO₂ reduction at a current density of 500 mA cm⁻² with CO FE of ca. 91%.

Ding Ma, Xing Xie, Yongyong Shi and colleagues report a genome-wide association study of cervical cancer in the Han Chinese population. They identify two new susceptibility lociat 4q12 and 17q12.

The lunar basalts sampled by the Chang’e-5 mission originated from melting of a clinopyroxene-rich mantle source enhanced in radioactive elements, potentially explaining this late lunar volcanism, according to sample analysis and crystallization modelling.

To run algorithms on a computer they are broken down into logical operations that are implemented in hardware. A quantum logical AND gate has now been demonstrated, which could substantially improve the efficiency of near-term quantum computers.

Here, the authors report a polymer-free transfer method to fabricate suspended 2D materials with high intactness and thermal conductivity, facilitating the application of graphene grids for high-resolution electron microscopy.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

The working mechanism of several low-cost electrocatalyst materials is still arguable. Here the authors show a model Fe,Mn/N-C catalyst where the oxygen reduction preferentially takes place on Fe(III) sites with the intermediate spin state (t2g4 eg1) caused by the adjacent Mn-N moieties.

Traditional optical microscope, while bulky, often fails to deliver optimal performance. Here, the authors have engineered an integrated microscope of 0.15 cm³ in volume and a weight of 0.5 g, which outperforms a commercial microscope and can be seamlessly integrated with a smartphone.

Hydroxylation at the C-14 position of triptolide is critical for its potent antitumor activity. Here, the authors report two CYP82Ds catalyze the 14-hydroxylation reaction via metabolic grid and achieve heterologous bioproduction of triptolide precursor in engineered Saccharomyces cerevisiae.

New alkenone results and existing temperature records together show contrasting Holocene temperature trends and thus display spatial patterns over mid-latitude Eurasia, with implications for the Holocene temperature conundrum.

Cotton plants are characterized by the presence of darkly pigmented glands that accumulate metabolites that contribute to plant defence but limit the use of cottonseed as food. Here, Ma et al. provide evidence that GoPGF, a bHLH transcription factor, is responsible for gland formation.

The X-ray crystal structure of ultraviolet-B-sensing protein UVR8 is determined, revealing that, unlike other known photoreceptors, the chromophore is not an external cofactor but rather two amino acids.

Many topological semimetals are excellent thermoelectric materials, but previous studies were limited to steady-state properties. Here, the authors observe a transient thermoelectric response in Cd₃As₂ by detecting the resulting THz emission, with an enhanced response when a small magnetic field is applied.

Ballistic avalanche phenomena in vertical InSe/BP heterostructures enable the demonstration of high-performance avalanche photodetectors and impact ionization transistors.

A nucleic acid immunoassay implemented on a lateral flow strip accurately detects SARS-CoV-2 RNA in less than one hour via a fluorescence readout.

This study reports a near-complete genome of Antirrhinum majus L., provides insights into gene and genome duplication events, and reveals the genetic basis underlying complex traits of snapdragon, such as flower asymmetry and self-incompatibility.

Tripterygium wilfordii is a medical plant that can produce antitumor activity compound triptolide. Here, the authors assemble its genome and identify a cytochrome P450 that can catalyze oxidation of a methyl to the acid moiety of dehydroabietic acid in triptolide biosynthesis by integrating multi-omics data.

Printed conductive inks show promise for future electronic device applications. Here, the authors report synthesis of graphene inks with conductivity of 7.13 × 10^4 S/m by Cyrene assisted liquid phase exfoliation, and their applications in data communication and RF energy harvesting.

There are multiple ways by which energy and charge transfer occur in weakly bound systems. Here the authors reveal a heavy ion N⁺ transfer in a doubly charged Van der Waals cluster produced in collisions of the highly charged Ne⁸⁺ ion with N₂Ar, leading to fragmentation of N⁺ and NAr⁺ via Coulomb explosion.

Magnetic meta-atoms made from lanthanum-doped barium hexaferrite can be used to create self-biased non-reciprocal metasurfaces capable of unidirectional transmission, non-reciprocal beam steering, non-reciprocal beam focusing and non-reciprocal holography.

Intrinsically disordered regions of GPCRs have been understudied for their role in receptor signaling. Here, Jie Heng et al. reveal the dynamic behavior of β2 adrenergic receptor C-terminus and its autoinhibitory function in downstream Gs coupling.

How neurons in the dorsal raphe nucleus (DRN) respond to reward related behaviours is not known. Here, Li and colleagues report that DRN serotoninergic neurons are phasically activated by rewards such as sex, food and sucrose, and tonically activated during reward anticipation, while GABAergic neurons respond to punishment.

KRas is frequently mutated in multiple cancer types; identifying drugs to treat such cancers is a good therapeutic strategy. Here, the authors perform a synthetic lethal screen in mice and show that inhibiting Plk1 and ROCK results in the inhibition of tumour growth by increasing expression of the tumour suppressor p21.

Deubiquitinases (DUBs) targeting Met1-linked ubiquitin chains have important functions in mammals but are barely studied in plants. Here, the authors identify rice OTUB1 as a Met1-targeting DUB, characterize the structural determinants of this activity, and show that these features are conserved in green plants.

Electric vehicles require careful management of their batteries and energy systems to increase their driving range while operating safely. This Review describes the technologies and techniques used in both battery and hybrid vehicles and considers future options for electric vehicles.

Single-atom catalysts maximize metal atom efficiency and exhibit properties that can be considerably different to their nanoparticle equivalent. Now a general host–guest strategy to make various single-atom catalysts on nitrogen-doped carbon has been developed; the iridium variant electrocatalyses the formic acid oxidation reaction with high mass activity and displays high tolerance to CO poisoning.

SspABCD–SspE is a widespread bacterial defence system against phage infection, in which SspABCD is responsible for introducing phosphorothioate modifications and SspE serves as a nickase that cleaves foreign DNA.

A method of deposition of mixed-cation hybrid perovskite films as lattice-mismatched substrates for an α-FAPbI₃ film is described, giving strains of up to 2.4 per cent while also stabilizing the metastable α-FAPbI₃ phase for several hundred days.

Jinghua Yang et al. provide the de novo assemblies of the transcriptomes of wasabi, horseradish and mustard to examine the evolution of specialized glucosinolates. This study demonstrates convergent evolution of super-accumulation of sinigrin in these taxa and may allow for potential strategies to engineer metabolic pathways of bioactive compounds for human food sources or pharmaceutical purposes.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Invasion of the gut by oral bacteria in liver cirrhosis.

Regulated proteolysis by ATP-dependent proteases have a crucial role in protein quality control in cells. The Clp/Hsp100 proteins of the AAA+ superfamily of ATP-dependent chaperones unfold and translocate proteins into the proteolytic chamber of protease complexes. ClpC requires the adaptor protein MecA for activation and substrate targetting to the ClpCP protease complex. Here, a structural and biochemical analysis is presented of the MecA–ClpC complex revealing organizational principles and providing mechanistic insights into this complex molecular machine.

Understanding the electromagnetic responses at subwavelength scales is important for achieving tunability. Using a combination of the near-field and far-field spectroscopy, the authors demonstrate a heavy fermion metamaterial with tunable dual-band optical responses by selectively and separately modifying the 4f and 5d band electrons.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

Fabricating lateral graphene p–n junctions with controlled doping levels is instrumental to realize ultrafast and efficient optoelectronic devices. Here, the authors report a seamless graphene based photodetector doped by selective ion implantation and in-situ chemical vapour deposition.

Hybrid halide perovskite single crystals show excellent optoelectronic properties but their small size and large thickness limit their application. Herein Liu et al. grow large area ultrathin flexible crystalline membrane of layered perovskite and demonstrate high detectivity in the flexible photosensors.