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Showing 1–4 of 4 results

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Publisher Correction: Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Yingjie Guo
Huan Zhang
Quan Chen
Amendments and Corrections22 Feb 2023
Nature Chemical Biology

Volume: 19, P: 530
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Guo et al. report a small molecule agonist of mitochondrial fusion that activates MFN1, an outer mitochondrial membrane protein, and protects cells from mitochondrial damage and ischemia/reperfusion injury in a mouse model.

Yingjie Guo
Huan Zhang
Quan Chen
Research12 Jan 2023
Nature Chemical Biology

Volume: 19, P: 468-477
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset

Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms sustained dimers even after GTP hydrolysis.

Yu-Jie Li
Yu-Lu Cao
Song Gao
ResearchOpen Access29 Oct 2019
Nature Communications

Volume: 10, P: 1-14
Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway

Meng-ping Liu
Min Liao
Mei-cun Yao
ResearchOpen Access27 Sept 2016
Scientific Reports

Volume: 6, P: 1-14