The authors show that type 2 dopamine receptors (D2Rs) negatively regulate spine morphogenesis in the hippocampi of adolescent mice. Spine deficiency resulting from D2R overactivation was associated with dysconnectivity in the entorhinal-hippocampal circuit and working memory deficits. These phenotypes could be rescued by D2R antagonists given during adolescence.
- Jie-Min Jia
- Jun Zhao
- Zheng Li
